HealthDay News — Programmed cell death 1 (PD-1) expression is associated with chronic rhinosinusitis with nasal polyps (CRSwNP) disease severity, according to a study published online January 25 in Allergy.

Inge Kortekaas Krohn, from the Catholic University of Leuven in Belgium, and colleagues measured expression of PD-1, its ligands PD-L1 and PD-L2, tumor growth factor-β, interleukin (IL)-5, and IL-10 mRNA by real-time polymerase chain reaction on tissue homogenates of 21 patients with CRSwNP and 21 healthy controls and on primary epithelial cells. 

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The researchers found that compared with controls, patients with CRSwNP had increased PD-1 mRNA expression regardless of the atopy status. PD-1 expression correlated with the total computed tomography scan scores. In control nasal tissue and in CRSwNP, there was a significant association between PD-1 mRNA and expression of IL-5 mRNA. Different subsets of T cells and CD11b dendritic cells had PD-1 expression. Primary epithelial cells from control nasal tissue and nasal polyp tissue had expression of both PD-1 and its ligands.

“Higher PD-1 expression was found in CRSwNP than in nasal tissue from controls,” the authors write. “This was associated with disease severity and tissue IL-5 expression but unrelated to the patients’ atopy status.”

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