HealthDay News — There is a bidirectional association between anorexia nervosa (AN) diagnosis and celiac disease (CD) in women, according to a study published online April 3 in Pediatrics.

Karl Mårild, MD, PhD, from the Norwegian Institute of Public Health in Oslo, and colleagues examined whether CD is associated with AN in a register-based cohort and case-control study. Data were included for 17,959 women with CD (diagnosed at a median age of 28 years) and 89,379 sex- and age-matched population-based controls. 

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The researchers found that 54 patients with CD were diagnosed with AN during 1,174,401 person-years of follow-up (27/100,000 person-years) compared with 180 matched controls (18/100,000 person-years). The hazard ratios for later AN and for AN beyond the first year after CD diagnosis were 1.46 (95% confidence interval, 1.08 to 1.98) and 1.31 (95 percent confidence interval, 0.95 to 1.81), respectively. There was also a correlation for previous AN diagnosis with CD (odds ratio, 2.18; 95% confidence interval, 1.45 to 3.29). After adjustment for socioeconomic characteristics and type 1 diabetes the estimates were largely unchanged.

“The bidirectional association between AN diagnosis and CD warrants attention in the initial assessment and follow-up of these conditions because underdiagnosis and misdiagnosis of these disorders likely cause protracted and unnecessary morbidity,” the authors write.

One author disclosed financial ties to Shire.

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