Increased caffeine intake from coffee may be associated with reduced risk of incident rosacea, according to a study published in JAMA Dermatology.

To better understand the relationship between rosacea and caffeine consumption, study authors evaluated data from the Nurses’ Health Study II, a prospective cohort established in 1989; in the cohort, women were asked about their intake of food and beverages including caffeine consumption (coffee, tea, soda, chocolate) every 4 years. Participants who responded to a question related to rosacea diagnosis in 2005 were included in the final analysis (N=82,737); 4,945 incident cases of rosacea were identified over 1,120,051 person-years of follow-up.

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Results showed that after adjusting for other risk factors, an inverse association was identified between increased caffeine intake and rosacea risk (hazard ratio [HR] for highest quintile of caffeine intake vs lowest: 0.76; 95% CI, 0.69-0.84; <.001 for trend), specifically with caffeinated coffee consumption (HR 0.77 for consumption of ≥4 servings/day vs consumption of <1 serving/month; 95% CI, 0.69-0.87; < .001 for trend). However, caffeine intake from food and other beverages was found not to be significantly associated with decreased rosacea risk.

“Many triggers for rosacea have been postulated, including caffeine, hot beverages, sunlight, spicy foods, strenuous exercise, and hormonal factors,” wrote the authors. “Our findings do not support limiting caffeine intake as a means to prevent rosacea and may have implications for the causes of and clinical approach to rosacea.”

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