The FDA has approved Botox (onabotulinumtoxinA injection; Allergan) for the treatment of urinary incontinence in patients with neurologic conditions (eg, spinal cord injury) and those with multiple sclerosis who have an overactive bladder. This approval was based on data from two clinical studies involving 691 patients with urinary incontinence resulting from spinal cord injury or MS. Both studies showed statistically significant decreases in the weekly frequency of incontinence episodes in patients who received Botox compared with placebo.

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