HealthDay News — The BNT162b2 (Pfizer-BioNTech) vaccine is highly effective against COVID-19-related hospital admission up to 6 months after full vaccination, according to a study published online October 4 in The Lancet.

Sara Y. Tartof, PhD, from Kaiser Permanente Southern California in Pasadena, and colleagues examined overall and variant-specific effectiveness of BNT162b2 against SARS-CoV-2 infections and COVID-19-related hospital admissions. Data were included for 3,436,957 individuals between December 14, 2020, and August 8, 2021.

The researchers found that effectiveness against SARS-CoV-2 infections was 73% for fully vaccinated individuals and 90% against COVID-19-related hospital admissions. There was a decline noted in effectiveness against infections, from 88% during the first month after full vaccination to 47% after 5 months. Vaccine effectiveness against infections of the delta variant was 93% during the first month after full vaccination and decreased to 53% after 4 months. Effectiveness against other variants declined from 97% during the first month after full vaccination to 67% at 4 to 5 months. For all ages, vaccine effectiveness against hospital admissions for infections with the delta variant was high overall up to 6 months (93%).

“Our study confirms that vaccines are a critical tool for controlling the pandemic and remain highly effective in preventing severe disease and hospitalization, including from the delta and other variants of concern,” Tartof said in a statement. “Protection against infection does decline in the months following a second dose.”


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Several authors disclosed financial ties to pharmaceutical companies, including Pfizer, which funded the study.

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