Eton Pharmaceuticals announced the availability of Biorphen (phenylephrine HCl) injection as the first ready-to-use injectable formulation of phenylephrine.

Biorphen, an α-1 adrenergic receptor agonist, is indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia. It is supplied as a 0.1mg/mL solution in 5mL single-dose ampules; this corresponds to 0.5mg of phenylephrine HCl per ampule, equivalent to 0.41mg of phenylephrine base. As the product is a ready-to-use formulation, it must not be diluted before administration. 

Biorphen is available in a pack of 10 ampules for ordering through wholesalers McKesson, AmerisourceBergen, and Cardinal Health and has a 3-year shelf life.

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“The availability of Biorphen reduces the need for hospitals to rely on compounders to provide unapproved compounded phenylephrine,” said Sean Brynjelsen, President and CEO of Eton. “In addition, Biorphen’s 3-year shelf life allows hospitals to more easily stock the product in operating rooms, emergency rooms, and crash carts.“

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