Bayer announced that it has updated the labels for its drospirenone-containing combination oral contraceptives (COCs) in the United States.

The updates include additional information from recent studies evaluating the risk of venous thromboembolism (blood clots) in women taking drospirenone-containing COCs.  It specifically states that these COCs may be associated with a higher risk of venous thromboembolism (VTE) than COCs containing levonorgestrel or some other progestins. In addition, the revised labels update information that there is a risk of VTE among all COCs, but that the risk of VTE associated with pregnancy is even greater than the risk associated with any COC use, including drsp-containing COCs. 

Bayer’s drospirenone-containing oral contraceptives include Yasmin, Yaz, and combination COCs Beyaz and Safyral (drospirenone, ethinyl estradiol and levomefolate calcium).

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