HealthDay News — Steroids reduce the risk for major adverse kidney outcomes in people with high-risk immunoglobulin A nephropathy (IgAN), but full-dose methylprednisolone increased the risk for serious adverse events, according to a study presented at Kidney Week, the annual meeting of the American Society of Nephrology, held virtually from November 4 to 7.
Vlado Perkovic, MBBS, PhD, from University of New South Wales in Sydney, and colleagues assessed the effects of oral methylprednisolone vs placebo on major kidney outcomes and safety in IgAN. In a double-blind trial, patients with high-risk IgAN were randomly assigned to methylprednisolone (257 patients) or placebo (246 patients). Following an excess of serious infections in the steroid arm, the methylprednisolone dose was reduced, and Pneumocystis jirovecii prophylaxis was added.
The researchers found that during an average follow-up of 4.2 years, methylprednisolone reduced the risk for the primary outcome (composite of 40% estimated glomerular filtration rate decline or kidney failure [dialysis, transplantation, or death due to kidney disease]; hazard ratio, 0.53) and end-stage kidney disease (hazard ratio, 0.59). This risk reduction was seen across both dose protocols (hazard ratios for full dose and reduced dose, 0.58 and 0.27, respectively). Serious adverse events were more common with steroids vs placebo (28 vs 7 patients), particularly with the full-dose vs the reduced-dose regimen.
“Steroids reduce the risk of major kidney outcomes and kidney failure in people with high risk IgAN,” the authors write.