Preoperative statins reduced cardiac complications and mortality in patients who underwent non-cardiac surgery, according to a new study presented at the European Society of Cardiology Congress 2015.
Dr. Otavio Berwanger, director of the Research Institute HCor, Hospital do Coraҫão in São Paulo, Brazil and colleagues, conducted the VISION (Vascular events In non-cardiac Surgery patIents cOhort evaluatioN) Study. This international, prospective, cohort study (n=15,478) assessed major complications post-cardiac surgery. For the current analyses, researchers looked at the effects of using perioperative statins on cardiovascular complications (including mortality) at 30 days.
Patients aged ≥45 years undergoing non-cardiac surgery were recruited from 12 centers in eight countries from August 2007 to January 2011. The primary endpoint was a composite of all-cause mortality, myocardial injury after non-cardiac surgery or stroke at 30 days. Secondary endpoints measured the individual components of the primary endpoint. The two arms were balanced out according to their prognostic baseline variables through a propensity score analysis: 2,845 patients were treated with a statin and 4,492 patients were not.
The use of preoperative statins resulted in 17% lower risk of cardiovascular complications (P=0.007), 43% lower risk of all-cause mortality (P=0.004), 52% lower risk of cardiovascular mortality (P=0.004), and 14% lower risk of myocardial injury (P=0.02) after non-cardiac surgery. The researchers concluded statins may be a potentially favorable intervention in preventing cardiovascular complications for patients undergoing non-cardiac surgery.
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