HealthDay News – Among patients with schizophrenia, long-term antipsychotic use does not appear to increase severe physical morbidity or somatic hospitalization, and mortality is lower for antipsychotic use compared with no use, according to a study published online January 10 in World Psychiatry.

Heidi Taipale, from the Karolinska Institutet in Stockholm, and colleagues assessed the risk for hospitalization due to physical health problems and the risk for mortality (all-cause, cardiovascular, or suicidal) among all patients treated for schizophrenia with antipsychotic agents in inpatient care in Finland during 1972 to 2014 (62,250 patients).

During a median follow-up of 14.1 years, the researchers found that the adjusted hazard ratio (aHR) for any somatic hospitalization was 1.00 (95% confidence interval [CI], 0.98 to 1.03) and the aHR for cardiovascular hospitalization was 1.00 (95% CI, 0.92 to 1.07) during use of any antipsychotic compared with nonexposure periods for the same individual. For all-cause mortality, the aHR was 0.48 (95% CI, 0.46 to 0.51), with 0.62 (95% CI, 0.57 to 0.67) for cardiovascular mortality and 0.52 (95% CI, 0.43 to 0.62) for suicide mortality during use vs nonuse of any antipsychotic. Specifically, with the use of clozapine, the aHR for all-cause mortality was 0.39 (95% CI, 0.36 to 0.43), with 0.55 (95% CI, 0.47 to 0.64) for cardiovascular and 0.21 (95% CI, 0.15 to 0.29) for suicide mortality. During follow-up, the cumulative mortality rates were 46.2% for no antipsychotic use, 25.7% for any antipsychotic use, and 15.6% for clozapine use.

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“Building trust and understanding towards the efficacy and safety of antipsychotic drugs is important, and we hope that this study can contribute to this end,” a coauthor said in a statement.

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