Analysis Identifies Uveitis Risk Factors in Ankylosing Spondylitis Patients

An analysis published in Medicine identified hip-joint lesion, prevalence of peripheral arthritis, and antistreptolysin O (ASO) and circulating immune complex (CIC) levels as risk factors that may be tied to higher rates of uveitis in ankylosing spondylitis.

An analysis published in Medicine identified hip-joint lesion, prevalence of peripheral arthritis, and antistreptolysin O (ASO) and circulating immune complex (CIC) levels as risk factors that may be tied to higher rates of uveitis in ankylosing spondylitis.  

The prevalence and characteristics of uveitis in patients with ankylosing spondylitis have been previously studied but its associated risk factors are not as clear. Researchers from China conducted a study (n=390) to analyze the risk factors of uveitis in patients with ankylosing spondylitis. Patients who met the modified New York criteria were enrolled from January to December 2015. Their medical records were retrospectively reviewed; data such as disease duration, HLA-B27, and the number of peripheral arthritis were collected as well. 

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Of the total patients with ankylosing spondylitis, 38 (9.7%) experienced one or more episodes of uveitis. Patients with uveitis had a higher incidence rate for hip-joint lesion vs. the non-uveitis group (44.7% vs. 22.2%; P<0.01). Peripheral arthritis prevalence was alsogreater for the uveitis group vs. the non-uveitis group (2.18 vs. 0.55; P<0.001). Significantly higher levels of ASO and CIC were seen in patients with uveitis (P<0.05 and P<0.0001, respectively) vs. patients without uveitis. 

However, study authors found no significant differences in disease duration, HLA-B27, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) between the two groups. ASO and peripheral arthritis (odds ratio [OR] 12.2 and OR 4.1; P<0.01 for both) were significantly associated with uveitis in ankylosing spondylitis according to a binary logistic regression analysis. 

Findings from this study suggest that the possibility of uveitis occurrence in patients with ankylosing spondylitis should not be ignored if they also have these risk factors.

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