Almost All Blood Donors Had SARS-CoV-2 Antibodies by Third Quarter of 2022

coronavirus antibody illustration
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47.7 percent of those ≥16 years had hybrid immunity, with the lowest prevalence seen for adults aged ≥65 years.

HealthDay News — Almost all blood donors had severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 antibodies from previous infection or vaccination by the third quarter of 2022, with the prevalence of hybrid immunity lowest for adults aged 65 years and older, according to research published in the June 2 issue of the US Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

Jefferson M. Jones, MD, from the CDC in Atlanta, and colleagues estimated the incidence of infection and prevalence of infection- or vaccination-induced SARS-CoV-2 antibodies using data from a nationwide, longitudinal cohort of blood donors.

The researchers found that an estimated 68.4% of persons aged 16 years and older had infection- or vaccination-induced SARS-CoV-2 antibodies during the second quarter of 2021, including 47.5, 12.0, and 8.9% from vaccination alone, infection alone, and both, respectively. Overall, 96.4% had SARS-CoV-2 antibodies by the third quarter of 2022, including 22.6, 26.1, and 47.7% from infection alone, vaccination alone, and hybrid immunity, respectively. Adults aged 65 years and older had the lowest prevalence of hybrid immunity (36.9%), and they had the highest risk for severe disease if infected; the prevalence of hybrid immunity was highest among those aged 16 to 29 years (59.6%).

“Compared with vaccine effectiveness against any infection and against severe disease or hospitalization, the effectiveness of hybrid immunity against these outcomes has been shown to be higher and wane more slowly,” the authors write.

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