(HealthDay News) – Multivitamins do not reduce the risk of major cardiovascular events, according to a study published in the Nov 7 issue of the Journal of the American Medical Association to coincide with presentation at the American Heart Association’s Scientific Sessions 2012, held from Nov 3–7 in Los Angeles.
Howard D Sesso, ScD, MPH, from Brigham and Women’s Hospital and Harvard Medical School in Boston, and colleagues analyzed data from 14,641 male U.S. physicians (mean age, 64.3 years), including 754 men with a history of cardiovascular disease (CVD), participating in the Physicians’ Health Study II, a randomized, double-blind, placebo-controlled trial of a common daily multivitamin.
During a median follow-up of 11.2 years, the researchers identified 1,732 confirmed major cardiovascular events. A daily multivitamin had no significant effect on major cardiovascular events compared with placebo (11 and 10.8 events per 1,000 person-years, respectively; P=0.91). A daily multivitamin had no impact on total myocardial infarction (MI) (3.9 and 4.2 events per 1,000 person-years; P=0.39); total stroke (4.1 and 3.9 events per 1,000 person-years; P=0.48); CVD mortality (5.0 and 5.1 events per 1,000 person-years; P=0.47); or total mortality (P=0.13). There was no difference between men with or without a history of CVD for the effect of a daily multivitamin on major cardiovascular events.
“Among this population of U.S. male physicians, taking a daily multivitamin did not reduce major cardiovascular events, MI, stroke, and CVD mortality after more than a decade of treatment and follow-up,” the authors write.
Several authors disclosed financial ties to the nutrition and pharmaceutical industries. BASF Corporation, Pfizer, and DSM Nutritional Products provided the study drugs and packaging.