IDWEEK 2016 – HIV

Retrospective chart reviews were conducted for Black, genotype 1 (GT1), HIV/HCV co-infected patients treated with ledipasvir/sofosbuvir (LDV/SOF) at 3 hospitals.

Long-term use of proton pump inhibitors (PPIs) might increase microbial translocation and innate immune activation but not enterocyte turnover or T-cell activation among people infected with HIV-1, according to research findings reported at IDWeek 2016.

HIV and hepatitis B virus (HBV) drugs had no impact on antiviral activity of grazoprevir or elbasvir, and neither agent affected HIV and HBV replication, a study presented at IDWeek has shown.

Together, depression and HIV infection are “strongly associated” with all-cause mortality in U.S. veterans, results from one of the largest analyses to date to examine this association reported at IDWeek 2016.

Vitamin D deficiency is prevalent among treatment-naïve HIV-infected patients, researchers reported at IDWeek 2016.

Use of protease inhibitors was associated with higher rates of liver aminotransferase elevations in patients with HIV; however, severe acute liver injury was uncommon with all antiretroviral therapy (ART) regimens, concluded a retrospective cohort study presented at IDWeek 2016.

The investigational anti-HIV integrase inhibitor cabotegravir (CAB) is well-tolerated, according to a meta-analysis of clinical trial data reported at IDWeek 2016.

Combined daily dolutegravir (DTV, 50 mg) and rilpivirine (RPV, 25 mg) is safe for HIV-infected patients previously treated with other regimens, according to findings from a small observational retrospective study reported at IDWeek 2016.

Switching patients 50 years of age or older infected with HIV from emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) to emtricitabine/tenofovir alafenamide (FTC/TAF) improved bone and renal safety compared with those who remained on FTC/TDF, study results reported at IDWeek have shown.

Among men who have sex with men (MSM), pre-exposure prophylaxis (PrEP) to prevent HIV infection is associated with increased risk of acquiring sexually transmitted infections (STIs), show results of a meta-analysis presented at IDWeek 2016. That could lead to antibiotic-resistant STIs, the authors warn.