Intravenous and oral delafloxacin (DLX) monotherapy, an investigational, full-spectrum anionic fluoroquinolone, exhibits tolerability and efficacy comparable to those for vancomycin/aztreonam (VAN/AZ) among adult patients with acute bacterial and skin structure infections (ABSSSI), including MRSA and gram-negative infections.
Both the tablet and intravenous (IV) formulations of posaconazole appeared to be safe and effective for primary prophylaxis against invasive fungal infections in patients with hematologic malignancies, according to results of a retrospective cohort study presented at IDWeek 2016.
Antibiotics overprescribing for patients with community-acquired pneumonia is a persisting and significant problem in the ICU, researchers reported at IDWeek 2016.
Ceftaroline fosamil is associated with improved clinical success rates in patients with gram-positive bacteremia, including MRSA and MSSA.
Use of proton pump inhibitors (PPIs) was tied to a higher risk of infectious gastroenteritis hospitalization with increasing risk among increasing doses.
Antiplatelet drugs are associated with a reduced risk of mortality among hospitalized patients with community-acquired pneumonia.
Patients with Pseudomonas aeruginosa bacteremia or pneumonia had a reduced 28-day all-cause mortality and length of stay in the intensive care unit (ICU) when administered an extended infusion of cefepime.
Patients given bezlotoxumab exhibited significantly less Clostridium difficile infection (CDI) recurrence regardless of choice of standard of care (SoC) antibiotics, according to a study presented at IDWeek.
Nafcillin was associated with greater acute kidney injury and in-hospital mortality vs. cefazolin.
Halting the spread of multidrug-resistant infections will require better drug stewardship, data sharing and coordination between facilities and countries, and a deeper appreciation for the role of the microbiome and healthy microbial ecosystems, according to US Centers for Disease Control and Prevention (CDC) Director Tom Frieden, MD.
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