|This article is part of MPR‘s coverage of CHEST 2018 meeting, taking place in San Antonio, TX. Our on-site staff will be reporting on the latest breaking research and clinical advances in infectious diseases. Check back regularly for highlights from CHEST 2018 meeting.|
SAN ANTONIO — Patients with moderate to severe persistent allergic asthma who were treated with omalizumab experienced greater improvements in lung function compared with those treated with placebo, according to findings from a post-hoc analysis presented at the CHEST Annual Meeting, held October 6-10, 2018, in San Antonio, Texas. Specifically, the current study investigated the short-term effects after 16 weeks of treatment with omalizumab.
A total of two phase 3 trials with 16-week omalizumab treatment data in moderate and severe allergic asthma were included in the analysis. Patients age ≥12 years were randomly assigned to either omalizumab (n=542) or placebo (n=529). At baseline, the mean (standard deviation) forced expiratory volume in 1 second (FEV1) was 2320mL (671; 68.2%±14.8% predicted) in the omalizumab group and 2353 mL (694; 67.7%±14.3% predicted) in the placebo group. Comparatively, the mean (standard deviation) forced vital capacity values at baseline were 3306mL (919) in the omalizumab group and 3349mL (968) in the placebo group.
At 16-week follow-up, there was significantly greater improvement in FEV1 values from baseline in patients taking omalizumab (least squares mean [LSM] difference 82 mL; 95% CI, 38-127 mL; P=.0003). Additionally, treatment with omalizumab was associated with a significantly greater improvement in percent predicted FEV1 (LSM difference 2.4; 95% CI, 1.2-3.6; P=.0001) as well as improvement in forced vital capacity compared with placebo (LSM difference 61 mL; 95% CI 2-120 mL; P=.04).
“Findings from this post hoc analysis demonstrate significant and rapid improvements in lung function in patients with moderate-to-severe persistent allergic asthma treated with omalizumab as early as 16 weeks,” the researchers concluded. “These data extend prior post-hoc findings demonstrating longer-term lung function benefit in patients following 28-52 weeks of treatment with omalizumab compared with placebo.”
Disclosures: Several authors report financial relationships with pharmaceutical companies.
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Hanania N, Lanier B, Iqbal A, Haselkorn T, Yoo B. Significant improvement in lung functioning following 16 weeks of omalizumab treatment: pooled analyses in patients with moderate-to-severe allergic asthma. Presented at: CHEST Annual Meeting 2018; October 6-10, 2018; San Antonio, TX.
This article originally appeared on Pulmonology Advisor