APS 2011 Acute Pain Coverage

APS 2011 Acute Pain

Pediatric Analgesia: Facilitating Clinical Trials

A multicenter pediatric pain clinical trials consortium will facilitate better study design and ensure children experience no additional burden for participation in research, including enduring even slightly undertreated pain, a panel of pediatric pain experts said during the American Pain Society’s 30th Annual Scientific Meeting.

Improved Pain, Functioning Observed in Patients with Moderate-to-Severe Osteoarthritis Treated with Fulranumab

Fulranumab, an investigational human recombinant monoclonal antibody (IgG2) to human nerve growth factor (NGF), improved pain and functioning in patients with inadequately controlled moderate-to-severe osteoarthritis pain of the hip and knee, according to results presented reported during the American Pain Society’s 30th Annual Scientific Meeting.

Assessment of Methadone on the QTc-Interval Prolongation

Controversy surrounds the issue of methadone-induced QTc-interval prolongation (QTcP or torsades de pointes), and just who should have EKG testing and when. According to study results presented at the American Pain Society’s 30th Annual Scientific Meeting, there is a dose-dependent effect on QTcP in patients taking <120mg/day of methadone compared with lower doses.

Muscle Relaxants May Not Always Cause Drowsiness When Effective: A Post-Hoc Analyisis of Cyclobenzaprine ER

Approximately half of patients treated for acute, painful muscle spasm responded to cyclobenzaprine extended-release with little to no drowsiness, challenging the common medical belief that sedation is integral to efficacy of skeletal muscle relaxants, as reported today during the American Pain Society’s 30th Annual Scientific Meeting.