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CHICAGO — Bisphosphonate exposure during pregnancy may not be linked to major teratogenic risks, according to a study presented at the 2018 ACR/ARHP Annual Meeting held October 19-24, 2018, in Chicago, Illinois.
Utilizing PubMed, Cochrane Library, and Ovid, researchers from Drexel University in Philadelphia examined the impact of bisphosphonate exposure on pregnancy and neonatal outcomes. The researchers included 15 case reports, 4 case series, and 4 cohort studies in which 120 preconception or pregnancy exposures to bisphosphonates were analyzed for impact on pregnancy or neonatal outcome.
After extensive evaluation, the authors concluded that the evidence for major teratogenic risk was low. There were 7 congenital malformations out of 120 exposures, including 2 cardiac valvular defects, 1 kidney malformation, and 2 bony malformative disorders.
In studies with a comparator group, congenital malformation and abortion rates were similar in those with bisphosphonates exposure compared with controls. Mean birth weight and gestational age were also only slightly lower in those with bisphosphonates exposure compared with the controls.
The researchers concluded, “preconception and pregnancy exposure to bisphosphonates does not pose major teratogenic risks.”
However, they stressed the importance of further controlled studies to fully establish the safety of bisphosphonates in connection with pregnancy.
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Kaur S, Khaamesi M, Jayatilleke A. Bisphosphonates during pregnancy: a systematic review. Presented at: 2018 ACR/ARHP Annual Meeting; October 19-24, 2018; Chicago, IL. Abstract 2424.
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This article originally appeared on Rheumatology Advisor