Potential Sex Differences in Chronic Cough Triggers

Women with chronic cough in the United States and United Kingdom were more likely to have a higher number of cough triggers.

This article is part of MPR’s coverage of the American College of Allergy, Asthma & Immunology 2020 Annual Scientific Meeting, being held virtually from November 13-15, 2020.


Women with chronic cough in the United States and United Kingdom were more likely to have a higher number of cough triggers, according to the results of a recent study presented at the American College of Allergy, Asthma & Immunology (ACAAI) Annual Scientific Meeting.

Chronic cough triggers were evaluated via survey in individuals based in the United States and United Kingdom who self-reported chronic cough in the 2018 National Health and Wellness Survey. Questions included 7 possible cough triggers. Chronic cough was defined as coughing daily for at least 8 weeks. Respondents who smoked or vaped in the past year, as well as those taking glucocorticoids or angiotensin-converting enzyme inhibitors, were excluded.

Of the 408 chronic cough respondents, 296 were based in the United States and 112 in the United Kingdom. There were more women overall: 73% of the US group and 65% of the UK group. In both countries, women were younger than men and reported more cough triggers (US mean, 3.4 vs 2.4; P <.01; UK mean, 3.4 vs 2.4; P <.01).

Exercise, laughing, talking, and cold air were reported as triggers in US women,  significantly more often than in US men (exercise: 48% vs 31%; laughing: 46% vs 27%; talking: 51% vs 36%; and cold air/temperature change: 62% vs 42%; respectively). However, these differences were not seen the UK population, with the exception of laughing (44% women vs 18% men; P =.001).

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“[Women] with [chronic cough] reported more triggers than [men] among both the US and UK respondents,” the study authors concluded. “These findings are consistent with the clinical manifestation of cough hypersensitivity syndrome.”

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Reference

Bernstein J, Morice A, Fonseca E, et al. Cough triggers by gender: a population survey of US and UK adults with chronic cough. Presented at: the American College of Allergy, Asthma & Immunology (ACAAI) Annual Scientific Meeting (Virtual Experience); November 13-15, 2020. Abstract P501.

This article originally appeared on Pulmonology Advisor