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The following article features coverage from the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) Annual Meeting. Click here to read more of MPR‘s conference coverage. |
In adults with chronic rhinosinusitis without nasal polyps (CRSsNP), the addition of oral steroids may lead to greater symptomatic improvement, according to a study presented at the AAO-HNS 2021 Annual Meeting, held October 3-6 in Los Angeles, California.
This prospective trial randomly assigned patients to receive amoxicillin clavulanate with intranasal corticosteroid spray (group 1); amoxicillin clavulanate, intranasal corticosteroid spray, and 6-day prednisone course (group2); or amoxicillin clavulanate, intranasal corticosteroid spray, and 20-day prednisone course (group 3).
Patients (N=33) who presented to a rhinology clinic with a history of chronic rhinosinusitis, Lund-Mackay scores of 6 or greater, and no evidence of polyps on a nasal endoscopy were enrolled and completed a Sinonasal Outcome Test-22 (SNOT-22) questionnaire. At week 4, the SNOT-22 questionnaire, computed tomography scans, and nasal endoscopy were repeated.
In the pretreatment analysis of the 3 groups, the SNOT-22, Lund-Mackay, and Lund-Kennedy scores were not found to be significantly different (P =.62; P =.72; P =.57, respectively). By week 4, SNOT-22 score averages decreased among all 3 groups, but the differences were not found to be statistically significant (P =.52). Significant Lund-Mackay score changes were observed in group 2 (mean decrease, 1.7 points; P =.07).
Findings also showed no significant differences in Lund-Mackay scores posttreatment (P =.98) or in the percentage of patients who required sinus surgery within a year of study enrollment (P =.82)
Based on these results, the study authors concluded that in adults with CRSsNP, “the addition of oral steroids had the greatest reported symptomatic improvement, with no appreciated difference between a 6-day and a 20-day steroid course.”
Reference
Perez HA, Miles E, Vuong C, Church C, Seiberling K. Comparison of steroid regimens in management of CRSsNP. Presented at: AAO-HNS 2021 Annual Meeting; October 3-6, 2021; Los Angeles, CA.
