The following article features coverage from the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) Annual Meeting. Click here to read more of MPR‘s conference coverage.

Electronic cigarette use was found to be associated with several unintended otolaryngology-related side effects, according to findings presented at the AAO-HNSF 2021 Annual Meeting.

After conducting a literature search of several large databases, the study authors identified 32 studies that reported on side effects following e-cigarette use. Findings showed the most common unintended otolaryngology-related side effects were throat irritation, cough, mouth irritation and oral mucosal lesions.

Five studies described either complete or partial resolution of these adverse effects at follow-up (3-12 months). Negative voice outcomes were observed in 2 of the studies.

Of the studies included in the analysis, 4 reported on pediatric outcomes. A large proportion of users also reported concomitant tobacco use.  The study authors noted that a meta-analysis could not be performed because of significant study heterogeneity.

“The long-term impact of e-cigarette on the upper aerodigestive tract is not known given the recent emergence of this technology,” they concluded, adding that further study is warranted to determine product safety.


Amanian A, Phulka J, Hu A. Side effects of electronic cigarettes in otolaryngology: Scoping review. Presented at: AAO-HNSF 2021 Annual Meeting; October 3-6, 2021; Los Angeles, CA.