Non-Allergic Rhinitis Symptoms Improved With Capsaicin

This article is part of MPR‘s coverage of the American Academy of Allergy, Asthma & Immunology annual meeting, taking place in San Francisco, California. Our staff will report on medical research related to asthma, allergy, and other respiratory conditions, conducted by experts in the field. Check back regularly for more news from AAAAI 2019.


SAN FRANCISCO — Patients with non-allergic rhinitis who received capsaicin exhibited rapid relief of symptoms compared with control patients, according to the results of a study presented at the Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI), held February 22-25 in San Francisco, California.

Electronic diary records of instantaneous and reflective nasal symptoms were examined in patients with non-allergic rhinitis given either capsaicin (n=23) or placebo (n=23) via nasal spray 1 to 2 times per nostril each day up to 8 times per day for 14 days. Time of first relief of symptoms was measured by patients using a stopwatch and compared between groups.

In the capsaicin group, instantaneous and reflective nasal symptoms significantly improved from as early as 10 minutes postdosing, and this improvement lasted up to 60 minutes after the dose. Furthermore, 52.2% showed relief <1 minute and 74.0% of patients showed relief for all the symptoms <2 minutes from time of the first dose.

The researchers noted that the nasal spray was generally well-tolerated and did not raise any safety concerns, and their findings confirmed the results from a previous study with the same product.

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Couroux PR, Ismail B, Houtman D, Khadari T, Salapatek AM. Capsaicin nasal spray showed significant and rapid relief in all nasal symptoms in subjects with non-allergic rhinitis. Presented at: American Academy of Allergy Asthma and Immunology Annual Meeting 2019; February 22-25, 2019; San Francisco, California. Abstract 191.