Table 1
Pairwise Comparison of Pharmacotherapies for Agitation
(Based on PANSS-EC Score)

Agents Number of Trials Findings (60min) Findings (120min)

Olanzapine vs haloperidol


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4

Significant difference in change favoring olanzapine

No significant difference

Loxapine inhaled 5mg vs loxapine inhaled 10mg

3

No statistically significant difference, although results appeared to favor loxapine 10mg

Statistically significant difference favoring loxapine 10 mg

Haloperidol vs risperidone

2

No significant difference

No significant difference

Olanzapine vs lorazepam

1

No data reported

Significant superiority of olanzapine

Aripiprazole vs lorazepam

1

No data reported

No data reported

Haloperidol vs risperidone+clonazepam

1

No data reported

No significant difference

Haloperidol vs aripiprazole

2

No significant difference

No significant difference

Risperidone+lorazepam vs haloperidol+lorazepam

1

No data reported

No data reported

Olanzapine vs haloperidol+lorazepam

1

No data reported

No significant difference