Staving off Dementia?

Recent research suggests that Vitamin D deficiency is prevalent in AD and dementia patients, and that low 25(OH)D level may even be a risk factor for developing AD.9 A literature search of 10 study populations consisting of over 8,000 participants9 found that subjects with deficient Vitamin D status (25(OH)D <50nmol/L had a 21% higher risk of developing AD or dementia, as compared to those whose level was above (25(OH)D <50nmol/L.


A growing evidence base supports the role of Vitamin D in nonskeletal conditions, suggesting that Vitamin D supplementation can be helpful in reducing risk and improving outcomes. The potential role of supplementation will continue to clarify as further evidence emerges.


  1. Manson JE, Bassuk SS. Vitamin D research and clinical practice: at a crossroads. JAMA. 2015;313(13):1311-1312.
  2. Glendenning P, Inderjeeth CA. Controversy and consensus regarding vitamin D: Recent methodological changes and the risks and benefits of vitamin D supplementation. Crit Rev Clin Lab Sci. 2015 Sep 17:1-16. [Epub ahead of print]
  3. Tanner SB, Harwell SA. More than healthy bones: a review of vitamin D in muscle health. Ther Adv Musculoskelet Dis. 2015 Aug;7(4):152-159.
  4. Coelho L, Cardoso SW, Luz PM, et al. Vitamin D3 supplementation in HIV infection: effectiveness and associations with antiretroviral therapy. Nutr J. 2015;14(1):81.
  5. Mokry LE, Ross S, Ahmad OS, et al. Vitamin D and risk of multiple sclerosis: a Mendelian randomization study. PLoS Med. 2015 Aug 25;12(8):e1001866.
  6. Gruson D, Ferracin B, Ahn SA, et al. 1,25-Dihydroxyvitamin D to PTH(1-84) Ratios strongly predict cardiovascular death in heart failure. PLoS One. 2015 Aug 26;10(8):e0135427.
  7. Riverin BD, Maguire JL, Li P. Vitamin D supplementation for childhood asthma: a systematic review and meta-analysis. PLoS One. 2015 Aug 31;10(8):e0136841.
  8. Oguz Topal I, Kocaturk E, Gungor S, et al. Does replacement of vitamin D reduce the symptom scores and improve quality of life in patients with chronic urticaria? J Dermatolog Treat. 2015 Sep 2:1-4. [Epub ahead  of print]
  9. Shen L, Ji HF. Vitamin D deficiency is associated with increased risk of Alzheimer’s disease and dementia: evidence from meta-analysis. Nutr J. 2015;14(1):76.