NSAID Use for Common CVD Comorbidities

The analgesic and anti-inflammatory effects of NAIDs are responsible for their use in a wide array of pain and rheumatologic conditions, including perioperative analgesia in both cardiac and noncardiac surgery, rheumatoid arthritis (RA), osteoarthritis (OA), and pericarditis. However, even their short-term use for these conditions increases risk in patients with underlying CVD.3


Recommendations for administration of NSAIDs in patients with CVD are listed in Table 1.


The authors state, “Given a rapidly aging population, with an increased prevalence of OA, RA, and other conditions where NSAIDs may provide symptomatic relief, a careful assessment of the individual risks and benefits should be conducted before initiating NSAID therapy.” They add that patients “should also be encouraged to report nonprescription NSAID use during medication history taking” and that patients should be “educated on the risks of continued NSAID therapy.”