Table 1
Findings Suspicious of FH
Age Untreated Fasting Cholesterol Concentrations Physical Manifestations*
< 20 years
  • LDL-C: ≥ 160mg/dL
  • Non-HDL: ≥ 190mg/dL
  • Tendon xanthomas
  • Arcus cornea
  • Xanthelasma
≥ 20 years
  • LDL-C: ≥ 190mg/dL
  • Non-HDL: ≥ 220mg/dL
  • Tendon xanthomas
  • Arcus cornea (in patients > 45 years)
*Absence of these manifestations should not be used to exclude diagnosis.
Patel et al. Pharmacotherapy. 2015. Dec;35(12):1189-203.1
Table 2
Tools for Formally Diagnosing FH
  • US Make Early Diagnoses Prevent Early Deaths Program Diagnostic (MEDPED) Criteria
  • The Dutch Lipid Clinic Network
  • Simon Broome Registry
Hopkins et al. J Clin Lipidol. 2011 Jun;5(3 Suppl):S9-17.2

Table 3
FH Patients at Highest Risk of CVD
  • Established CVD
  • Diabetes mellitus
  • Family history of premature CHD
  • Smokers
  • Two or more of the following risk factors
    • Men > 30 years
    • Women > 40 years
    • Baseline LDL-C > 250 mg/dL
    • Male sex
    • Current smoker
    • Premature on set of CHD in first-degree man >55 years or first-degree women < 65 years
    • Metabolic syndrome
    • HDL-C < 40 mg/dL
    • Hypertension
    • Lipoprotein(a) ≥ 50 mg/dL
    • Tendon xanthoma
Patel et al. Pharmacotherapy. 2015. Dec;35(12):1189-203.1



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References

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