Figure 1 — Suggested Treatment Algorithms for MS1

Table 2 — Factors That May Indicate Use of Aggressive Treatment1

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• Greater number of T2 weighted brain MRI lesions at presentation of CIS (e.g. >10 lesions)
• Greater initial lesion volume
• Early change in volume
• Early attack rate
• Presence of multiple gadolinium enhancing MRI lesions
• Significant T2 lesion burden
• Increase in EDSS score within the preceding year
• Detection of T1 black holes or cerebral atrophy
• African-American race

Abbreviations:CIS – clinically isolated syndrome; EDSS – Extended Disability Status Scale