They cited the recommendations by Glickman-Simon and Pettit14 to improve the design of future RCTs that investigate whether there is a therapeutic role for vitamin D in treating depression. The authors also added several recommendations of their own.

RCTs should:

·         Enroll only depressed patients deficient in vitamin D

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·         Administer a standardized oral dosage

·         Measure post-treatment vitamin D levels to ensure that they are now within the normal range

·         Examine improvements, both in relation to formalized clinical depression disorders and depression severity

·         Evaluate vitamin D supplementation as monotherapy, rather than as augmentation in those already taking antidepressants


Despite their caveats and concerns, the authors nevertheless concluded from the cross-sectional and longitudinal studies that there is “increasing evidence of an increased risk for depression in those who are vitamin D deficient, and that vitamin D supplementation is of benefit for depressed individuals who are vitamin D deficient.”


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