Cost, How Supplied, Dose

MSM is chiefly supplied as either powder-filled capsules or in compounded creams with other ingredients such as glucosamine sulfate. Powder-filled 1,000mg capsules of MSM cost $5 to $10 per 100 capsules, depending on the supplier.

Studies of oral MSM for large-joint osteoarthritis typically used at least 6g per day, usually in two divided doses. Safety studies have shown no unanticipated adverse reactions at these doses for up to three weeks with tolerability that is similar to topical blends.8

Summary

The idea of a compound that is nearly harmless but possibly relieves some of the country’s tremendous burden of osteoarthritis pain is appealing. However, there is still a lack of robust data to determine the true efficacy of MSM in this condition. It is quite possible, however, that future research will find an even bigger role for MSM in cancer detection and treatment.

Sherril Sego, FNP-C, DNP, is a staff clinician at the VA Hospital in Kansas City, Mo., where she practices adult medicine and women’s health. She also teaches at the nursing schools of the University of Missouri and the University of Kansas. 


References

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  7. Kwak J, Gallagher M, Ozdener MH, et al. Volatile biomarkers from human melanoma cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;931:90-96. 

  8. Bauer BA. Are there any adverse effects from long-term use of MSM for arthritis pain? Mayo Clinic Web site. Published June 6, 2014. Available at mayoclinic.org/
diseases-conditions/arthritis/expert-answers/msm/faq-20058526 

  9. Engelke UF, Tangerman A, Willemsen MA, et al. Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR. NMR Biomed. 2005;18(5):331-336.


All electronic documents accessed June 3, 2015.


This article originally appeared on Clinical Advisor