The management of enteropathy is not only multifaceted, but also poses many challenges.1 Treatment typically focuses on the combination of symptomatic relief and glycemic control. Once a patient has been clinically evaluated for suspected enteropathy and other possible causes of presenting symptoms are excluded, a stepwise therapeutic strategy is implemented. This approach includes nutritional counseling, blood glucose control, and the management of diarrhea, fecal incontinence, abdominal pain, and constipation. Figure 2 displays the treatment algorithm that should be used for patients presenting with diabetic enteropathy.

Research indicates that nearly three-quarters of patients with diabetes experience GI symptoms.1 Diabetic GI manifestations include gastroparesis and diabetic enteropathy, both of which significantly decrease a patient’s quality of life. Although the treatment is challenging, a combination of symptomatic management and glycemic control has been found to be effective in treating a patient’s enteropathy.


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1. Maisey, A. A Practical Approach to Gastrointestinal Complications of Diabetes. Diabetes Ther. 2016 July 18; DOI: 10.1007/s13300-016-0182-y.

Figure 1 — Management of Gastroparesis1

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Abbreviations: DPP-4 inhibitors – dipeptidyl peptidase-4 inhibitors; GLP-1 agonists – glucagon-like peptide-1 receptor agonists

Table 1 — Potential Causes For Symptoms of Enteropathy1

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Figure 2 — Treatment Algorithm for Diabetic Enteropathy1

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