The authors note that the increasing focus on cardiovascular safety has necessitated large prospective post-marketing studies of new diabetes agents. Increasing understanding of the “molecular underpinnings of diabetes and HF” are leading to the development of “rational drug targets with the goal of reducing myocardial insulin resistance and oxidative stress.” The authors state that the SGLT-2 inhibitors raise “the exciting possibility of improved outcomes in HF.” However, further research is needed to determine “whether these agents will improve disease-specific symptoms, quality of life, ejection fraction, and other important clinical endpoints.”


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