Importantly, this case study shows the possibility of liver damage with long-term daptomycin treatment in the absence of CK elevations, myopathy, or kidney dysfunction. With this finding, although more research is needed, the authors suggest that clinicians be aware of the possible hepatic adverse effects daptomycin can have. Because of this, they propose that patient’s LFTs be closely monitored prior to, and periodically throughout daptomycin therapy.


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