The authors concluded that the ability of SGLT-2 inhibitors to “reduce other important parameters” beyond glycemic control, including body weight and BP, demonstrates “a positive impact on relevant cardiovascular risk factors.” Despite some difference between individual agents, “all of the approved SGLT-2 inhibitors provide a mild but meaningful reduction up to 5/3 mmHg in office SBP and DBP as monotherapy or add-on therapy.” They noted that preliminary studies also suggest impact on ABPM. They emphasized that the beneficial impact on BP is dose-dependent.


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