It is recognized that many other medications have been proposed as adjunct medications for these disorders, including various antidepressants, benzodiazepines, amino acids, and indigenous and herbal remedies. It is not the purpose of this paper to include these other medications, but merely to focus on selected compounds with which we have had some direct experience. A summary of these nine drugs follows, listed alphabetically. SMRI has supported many of the previous trials for these drugs and, in each case, is currently supporting additional trials.
None of these medications have yet been conclusively established as proven adjunct medications, but for each there are suggestions that they might be useful and should, thus, be considered in treatment-resistant cases when the clinician is out of other treatment options. The use of drug combinations has been very useful for diseases such as hypertension and AIDS, especially when the drugs act through different mechanisms. Many of these repurposed drugs are thought to act through mechanisms different from mechanisms used by standard antipsychotics and mood stabilizers and, thus, could ultimately lead to new classes of drugs for these conditions.