Hypertension Treatments: Oral CCBs
HYPERTENSION TREATMENTS: ORAL CCBs
Generic Brand Strength Form Usual Dose
DIHYDROPYRIDINES
amlodipine Norvasc 2.5mg, 5mg, 10mg tabs Adults: 5mg once daily. Adjust at 7–14 day intervals; usual max 10mg/day. Small, fragile, elderly, hepatic impaired, patients on other antihypertensives: 2.5mg once daily.
Children: <6yrs: not established. 6–17yrs: 2.5–5mg once daily.
felodipine 2.5mg, 5mg, 10mg ext‑rel tabs Adults: Initially 5mg once daily. Range 2.5–10mg once daily. Adjust at 2wk intervals; max 10mg/day. Elderly or hepatic dysfunction: initially 2.5mg once daily.
Children: Not established.
nicardipine 20mg, 30mg caps ≥18yrs: Initially 20mg 3 times daily; adjust at intervals of at least 3 days; max 120mg/day. Severe hepatic impairment: initially 20mg twice daily.
<18yrs: Not established.
nifedipine 30mg, 60mg, 90mg ext‑rel tabs Adults: Initially 30mg once daily. Usual maintenance: 30–60mg once daily. Titrate over 7–14 days; max 90mg/day.
Children: Not established.
Procardia  XL 30mg, 60mg, 90mg ext‑rel tabs Adults: Initially 30 or 60mg once daily, titrate over 7–14 days; max 120mg/day.
Children: Not established.
nisoldipine Sular 8.5mg, 17mg, 34mg ext‑rel tabs Adults: Initially 17mg once daily; may increase by 8.5mg per week or longer intervals. Usual maintenance: 17–34mg once daily; max 34mg/day. Hepatic impairment or elderly (>65yrs): initially 8.5mg once daily.
Children: Not established.
NON-DIHYDROPYRIDINES
diltiazem Cardizem LA 120mg, 180mg, 240mg, 300mg, 360mg, 420mg ext‑rel tabs Adults: Initially 180–240mg once daily; adjust at 2wk intervals up to max 540mg/day. Concomitant simvastatin: max 240mg/day.
Children: Not established.
Cardizem  CD 120mg, 180mg, 240mg, 300mg, 360mg ext‑rel caps Adults: Initially 180–240mg once daily; adjust at 2wk intervals. Usual range: 240–360mg once daily; usual max 480mg/day. Concomitant simvastatin: max 240mg/day.
Children: Not established.
Tiazac 120mg, 180mg, 240mg, 300mg, 360mg, 420mg ext‑rel caps Adults: Initially 120–240mg once daily; adjust at 2wk intervals; usual max 540mg/day.
Children: Not established.
verapamil 40mg, 80mg+, 120mg+ tabs ≥18yrs: Initially 80mg 3 times daily; usual max 360mg/day in divided doses. Elderly, small patients: initially 40mg 3 times daily.
<18yrs: Not established.
Calan SR 120mg, 240mg+ sust-rel caplets ≥18yrs: Initially 180mg in the AM; may titrate to max 480mg/day in divided doses. Elderly, small patients: initially 120mg in the AM.
<18yrs: Not established.
Verelan 120mg, 180mg, 240mg, 360mg sust-rel caps ≥18yrs: usually 240mg daily in the AM; adjust in 120mg increments. Elderly, small patients, others with increased sensitivity: 120mg daily; if needed, may increase to 180mg/day, then 240mg/day, then higher in 120mg increments. Max 480mg/day.
<18yrs: Not established.
Verelan PM 100mg, 200mg, 300mg controlled onset ext‑rel caps Adults: Initially 200mg once daily at bedtime; may titrate upwards in steps to 300mg, then 400mg if needed. Elderly, small patients, renal or hepatic impairment: initially 100mg once daily.
Children: Not established.
NOTES

Key:  + = scored

Not an inclusive list of medications, official indications and/or doses. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling. Individualize dose. Initially may start at lower doses in certain patient populations. May be confused with other products with similar names. Ensure that the patient receives the appropriate product.

With few exceptions, ext-rel and sust-rel products should not be crushed, chewed, or divided to preserve the products’ release characteristics.

(Rev. 7/2021)