Geriatrics

Treatment for Alzheimer-Related Agitation Gets Fast Track Status

By July 16, 2018

Currently, there are no approved treatments for behavioral symptoms (eg, aggression, agitation) in Alzheimer's disease.

Immunogenicity of Co-Administered Herpes Zoster, Pneumonia Vaccine Assessed

By July 06, 2018

In this Phase 3, open-label, randomized, controlled multicenter study, a total of 865 patients were randomized to receive one of the following vaccine regimens: (1) the first RZV dose and PPSV23 together on Day 0 and the second dose of RZV at Month 2 (N=432); or (2) PPSV23 on Day 0 and then first RZV dose at Month 2 with the second RZV dose at Month 4 (N=433; control group).

Umeclidinium/Vilanterol Efficacy Assessed in Elderly COPD Patients

By July 06, 2018

Study authors performed a post hoc pooled analysis of data from 10 trials to assess the safety and efficacy of umeclidinium/vilanterol in elderly symptomatic patients with COPD.

Hepatitis B Vaccines Compared in Older Adults With Type 2 Diabetes

By June 26, 2018

For the analysis, study authors looked at data specifically for patients with type 2 diabetes aged 60 to 70 years.

Insulin Glargine 300 Safe, Effective in Seniors With T2DM

June 26, 2018

The researchers found that from baseline to week 26, the reductions in HbA1c were comparable for Gla-300 and Gla-100 in the overall population and for participants aged ≥75 years.

Direct-Acting Antivirals Effective for Hepatitis C in Seniors

June 26, 2018

The researchers found that the sustained virologic response rate was 97.7 and 95.8% in individuals aged 65 to 74 years and those aged 75 years and older, respectively.

Rivaroxaban Use in Older Patients: Does Age Influence Safety, Efficacy?

By June 25, 2018

Data from large Phase 3 studies showed that treatment with rivaroxaban was found to be safe and effective in older patients.

Older Age Tied to Poorer Course of Major Depressive Disorder

June 08, 2018

Results were slightly attenuated but remained mostly significant with adjustment for prognostic factors

Survey-based intervention linked to improved communication and goals-of-care discussions

June 06, 2018

Goals-of-care (GOC) discussions were linked to improved patient outcomes and reduction of intensity in end-of-life care. The current study demonstrated that a survey-based intervention for priming clinicians with communication strategies was linked to increase in the occurrence, documentation, and quality of GOC discussions.

FDA: Updated Safety Alert Regarding Benzocaine-Associated Methemoglobinemia

By May 23, 2018

The Agency is urging manufacturers to stop marketing OTC oral drug products containing benzocaine for teething to this patient population.

AUA: Guideline on Surgical Management of BPH-Related Lower Urinary Tract Symptoms

By May 17, 2018

The new guideline includes 22 recommendations focused on utilizing common surgical techniques and minimally invasive surgical therapies.

Midstream Urine Microbiome Diverse in Seniors With CKD

May 14, 2018

The remaining samples lacked a dominant genus. High levels of diversity were seen in the samples, as measured by the inverse Simpson, Chao, and Shannon indices.

Tips on Improving Communication With Older Patients

By May 10, 2018

Communication with older patients can be complicated for several reasons.

Positive Results Announced for Esketamine in Treatment-Resistant Depression

By May 07, 2018

In both studies, the primary efficacy endpoint was change from baseline to Day 28 in Montgomery-Åsberg Depression Rating Scale (MADRS) total score.

Pharmacists Can Play Role in Identifying Frailty

May 07, 2018

Community pharmacists can identify certain risk factors for frailty, including gender, low socioeconomic status, chronic illnesses, neuroendocrine dysfunctions, and certain medications and medication regimens.

Older Adults Agree Sex Is Important Part of Relationships

May 03, 2018

Forty percent indicated that they were currently sexually active; sexual activity decreased with age. More than half (54%) of respondents agreed that sex is important to their overall quality of life, with men more likely to agree than women (70 versus 40%).

Survey Reveals Barriers to Deprescribing for Elderly Patients

May 02, 2018

Lack of time and difficulty engaging patients, caregivers reported as barriers to deprescribing

Anticholinergic Drug Use and Dementia: What's the Link?

By April 26, 2018

A total of 14,453 (35%) cases and 86,403 (30%) controls were prescribed at least 1 anticholingeric drug with an Anticholinergic Cognitive Burden (ACB) score of 3; 1429 (3.5%) cases and 7909 (2.8%) controls were prescribed drugs with an ACB score of 2; most patients (89% of cases and 87% of controls) received a drug with an ACB score of 1 during the drug exposure period (DEP).

Overactive Bladder & Urinary Incontinence Treatments

April 23, 2018

Overactive bladder and urinary incontinence dosing regimen chart for anticholinergics, antispasmodic/anticholinergics, muscarinic antagonists, and synthetic vasopressin.

Annual Visits May Not Increase Cognitive Impairment Detection

April 23, 2018

The researchers found that there were no clinically relevant differences between the Medicare Annual Wellness Visits group and matched controls in the rates of incident Alzheimer's disease and related dementia (ADRD) diagnoses.

USPSTF: Exercise Interventions Prevent Falls in Seniors

April 18, 2018

The harms of exercise and multifactorial interventions was found to be no greater than small. Based on these findings, the USPSFT recommends exercise interventions to prevent falls among those at increased fall risk (B recommendation).

Untrimmed Toenails: A Marker of Functional Status in Older Patients?

By April 13, 2018

For older patients, toenail length can provide important insight into a patient's functional status.

ACA Marketplaces Expand Coverage for Chronically Ill

April 06, 2018

Researchers found that the Affordable Care Act's Marketplaces covered a disproportionate share of non-elderly adults with high health care risks in the 2014 to 2015 time period.

2018 Vaccination Schedule: Adults

April 02, 2018

This schedule indicates the recommended age groups and medical indications for routine administration of currently licensed vaccines for persons 19 years and older.

Impact of Mediterranean Diet on Aging Examined

By March 30, 2018

In general, researchers highlight 5 key adaptations seen with adhering to the Mediterranean diet pattern: Lipid lowering, protection from oxidative stress and inflammation, modification of growth factors that can promote cancer, Inhibition of nutrient sensing pathways by amino acid restriction, and gut microbiota-mediated production of metabolites.

'Nontrivial' Number of Seniors Lack a Personal Physician

March 28, 2018

"Even with the access provided by Medicare, a small but nontrivial proportion of seniors report having no personal physician," the authors write. "Efforts should be made to encourage and help seniors without personal physicians to select one."

DMT Discontinuation in Older MS Patients: Clinical Outcomes Examined

By March 21, 2018

Of the total patients, 178 (29.7%) discontinued DMT during the study period with only 1 documented relapse occurring in the discontinuers.

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

By March 15, 2018

The study included 110,184 adults (mean age: 76 years) newly started on gabapentin therapy in Ontario, Canada.

Excessive Daytime Sleepiness Linked to β-Amyloid Accumulation in Elderly

March 13, 2018

The researchers found that baseline EDS, defined as an Epworth Sleepiness Scale score of at least 10, was significantly correlated with increased regional Aβ accumulation in the anterior cingulate, posterior cingulate-precuneus, and parietal regions.

Pharmacists Encouraged to Learn More About Herbal Supplements

March 08, 2018

Pharmacists should steer patients toward brands of herbal products that are reliable and unadulterated