Gastrohepatic Disorders

PPI co-therapy reduces gastrointestinal bleeding risk of oral anticoagulants

December 05, 2018

In this retrospective cohort study, rivaroxaban had the highest and apixaban had the lowest upper gastrointestinal bleeding risk.

Novel <i>H. pylori</i> Eradication Therapy Effective in Phase 3 Trial

By December 04, 2018

The ERADICATE Hp2 trial enrolled 455 dyspepsia patients at 55 sites across the US and randomized them to receive 4 capsules, 3 times daily, of either Talicia or the active comparator (amoxicillin 250mg and omeprazole 10mg), for a period of 14 days.

Hypnotherapy vs Education for Relief of IBS Symptoms

November 30, 2018

A total of 354 participants were randomly assigned to individual hypnotherapy, group hypnotherapy, and educational supportive therapy; after excluding ineligible participants, 142, 146, and 54 participants, respectively.

Ulcerative Colitis Treatments

November 28, 2018

Medications for the treatment, induction of remission, and maintenance of ulcerative colitis.

Bowel Cleansers

November 28, 2018

Bowel cleansing products comparison chart (hyperosmotics, isosmotics, isosmotic/stimulant laxative combinations, osmotics) used for colonoscopy preparation.

Novel NASH Treatment Gets FDA's Fast Track Designation

By November 28, 2018

The Company has completed a first in human study in healthy volunteers; a Phase 2 trial in adults with NASH is due to begin soon in the US.

Probiotics Show No Benefits for Pediatric Acute Gastroenteritis

November 26, 2018

No benefits seen with Lactobacillus rhamnosus GG or L. rhamnosus R0011 and L. helveticus R0052

FDA Approves Longer Shelf Life for Nityr Tablets

By November 20, 2018

HT-1 is a rare genetic disease that can cause hepatic, renal and peripheral nerve damage.

FDA Approves New Treatment for Travelers' Diarrhea

By November 19, 2018

Aemcolo is a broad spectrum, semi-synthetic, orally-administered, minimally-absorbed antibiotic designed to allow for delayed release to the colon.

DAA Treatment and Hepatic Fibrosis Improvement in HCV: What's the Link?

By November 13, 2018

The study aimed to determine whether direct-acting antiviral therapy reduced fibrosis and assessed whether any predictors of treatment failure existed at 1-year follow-up.

Avocado Implicated in Several Food Protein-Induced Enterocolitis Syndrome Cases

By October 29, 2018

FPIES is a gastrointestinal food-associated hypersensitivity that often affects infants and toddlers and is marked by vomiting, diarrhea, fatigue, and pallor.

Opiate-Free Surgery Feasible for Elective Colectomy

October 23, 2018

The researchers found that 83% of the patients required no narcotic medication postoperatively. Preoperative opioid use significantly predicted postoperative narcotic requirement.

Palonosetron Available in Prefilled Syringe for Chemotherapy-Induced Nausea, Vomiting

By October 22, 2018

The prefilled syringe is part of the Company's Simplist portfolio and is the first FDA-approved prefilled delivery version of palonosetron hydrochloride (HCI) to become available.

FDA Panel Votes on Prucalopride for Chronic Idiopathic Constipation

By October 19, 2018

The panel's decision was made based on data from from five Phase 3 studies and one Phase 4 trial which evaluated the safety and efficacy of prucalopride in patients with chronic constipation.

AGA: New Opioid-Induced Constipation Management Guidelines Available

By October 18, 2018

The recommendations have been published in the AGA's official journal, Gastroenterology.

Posttransplant Outcomes Assessed in Patients Who Resumed TNFi Therapy

By October 18, 2018

Of the 5256 patients who received a renal transplant in the study window (1/1/1998 - 12/31/2017), 14 met inclusion criteria.

Treatment for Alagille Syndrome Granted Orphan Drug Designation

By October 17, 2018

Alagille syndrome affects approximately 1 in 70,000 newborns.

Novel Blood Test for Irritable Bowel Syndrome Now Available

By October 10, 2018

The test works by measuring levels of anti-cytolethal distending toxin B (CdtB) and anti-vinculin, 2 biomarkers of post-infectious IBS-D and IBS-M.

Ustekinumab Induces Clinical Remission After One Dose in Ulcerative Colitis Study

By October 10, 2018

Study authors at the American College of Gastroenterology (ACG) Scientific Meeting 2018 presented late-breaking data from the induction phase of the Phase 3 UNIFI study.

GERD Diagnosis and Management Guidelines

By October 09, 2018

Expert recommendations for the diagnosis and management of gastroesophageal reflux disease (GERD).

Rituximab Linked to HBV Reactivation in Patients With Prior Functional Cure

By October 09, 2018

The study authors searched MEDLINE from inception through July 2018 to obtain relevant cohort studies and randomized trials assessing HBVr incidence secondary to pharmaceutical agents.

Probiotic Use May Not Protect Against <i>Clostridium Difficile</i> Infection

October 05, 2018

In patients taking multiple antibiotics, proton pump inhibitors, or histamine receptor antagonists, the concurrent use of probiotics was associated with an increased incidence of Clostridium difficile infection

Sucraid Supply Restored for Patients With Genetic Sucrase-Isomaltase Deficiency

By October 02, 2018

The Company stated that they are now able to meet all prescription demands for Sucraid without informed consent.

Proton Pump Inhibitor Use Tied to Hip Fracture in Dialysis Patients

September 28, 2018

The researchers found that a larger proportion of cases than controls had prior PPI use (70 vs 63%) or histamine-2 receptor antagonist use (25 vs 23%).

Irritable Bowel Syndrome Treatments

September 27, 2018

Drug therapy for the treatment of irritable bowel syndrome (IBS).

Antiemetic Treatments

September 26, 2018

Antiemetic treatment chart including drug formulations, strengths, and usual doses for nausea/vomiting.

Reflux Band Now Available OTC for Reducing Laryngopharyngeal Reflux

By September 26, 2018

In one study, 86% of patients clinically diagnosed with esophagopharyngeal reflux reported significant reduction in symptoms after 2 weeks of use.

Irritable Bowel Syndrome Evaluation

September 26, 2018

Irritable Bowel Syndrome (IBS) evaluation chart based on Manning Criteria and Rome III Diagnostic Criteria.

Antibiotic Tx Appears to Be a Reasonable Option for Uncomplicated Acute Appendicitis

By September 26, 2018

The study included 530 patients, aged 18 to 60 years, with computed tomography-confirmed uncomplicated acute appendicitis.