Gastrohepatic Disorders

Liver Disease, Insulin Resistance Associated With High Red Meat Consumption

March 20, 2018

The researchers found that after adjusting for body mass index, physical activity, smoking, alcohol, energy, saturated fat and cholesterol intake, the odds of NAFLD and IR were increased in association with high consumption of total meat.

Does Gut Bacteria Translocate to the Brain During Sepsis?

March 15, 2018

Among humans who died of sepsis, bacterial taxa detected in their brains were distinct from those who died of noninfectious causes and were correlated with S100A8/A9 expression.

FDA Clears New <i>H. pylori</i> Testing Option for Pediatric Patients

By March 13, 2018

The result comparisons found an overall agreement in the pre-therapy cohort between the breath test and the reference biopsy result of 98.3% (95 CI: 95.2%-99.7%).

Sollpura Falls Short in Exocrine Pancreatic Insufficiency Trial

By March 13, 2018

the Phase 3 'SOLUTION' study of Sollpura did not meet the primary endpoint of non-inferiority to an active-comparator in the coefficient of fat absorption (CFA).

Xeljanz Gets FDA Committee Nod for Ulcerative Colitis Indication

By March 09, 2018

The GIDAC recommendations are provided to the FDA but they are not binding. The FDA has set a target PDUFA action date of June 2018.

FDA Accepts NDA for Novel Chronic Idiopathic Constipation Treatment

By March 05, 2018

If approved, prucalopride will be the only readily available 5-HT4 agonist for adult CIC in the U.S.

Pancreatic Enzyme Replacement Therapy

March 02, 2018

Pancreatic enzyme (lipase, pancrease, amylase) replacement therapy comparison chart.

Limited Data on Combination Biologic Therapy for IBD, Says Study

By February 28, 2018

The authors point out how, unlike other autoinflammatory conditions, "IBD has the benefit of effective and safe gut specific anti-integrin therapies which can provide a platform off of which combinations can be employed."

Lusutrombopag Under Priority Review for Thrombocytopenia in Liver Disease

By February 26, 2018

The primary endpoint was the number of patients who required no platelet transfusion priory to primary invasive procedure and no rescue therapy for bleeding for 7 days post-procedure.

Modifiable Risk Factors ID'd in Recurring Acute Diverticulitis

February 23, 2018

"Knowledge of the rate and risk factors for recurrent acute diverticulitis is required to aid discussion and decision making with patients regarding the need and timing of elective surgery," the authors write.

Sudden Sensorineural Hearing Loss Recovery Lower in Metabolic Syndrome

February 16, 2018

The researchers found that the groups with and without metabolic syndrome had similar mean pure-tone audiometry thresholds at baseline but that recovery rates after treatment were significantly lower in the metabolic syndrome group.

Treatment With Homemade Enema Leads to Colitis in Two Children

By February 14, 2018

A national survey showed that only about 7% of consumers read warning labeling on over-the-counter products.

Drinking Water Quality Violations Widespread, Says New Report

February 13, 2018

In locations of violation hot spots, repeat violations were prevalent, indicating that water systems struggle with recurring issues in these regions.

New Guidelines Focus on Early Treatment Decisions in Acute Pancreatitis

By February 12, 2018

The guidelines are intended to reduce practice variation and promote high-quality and high-value care.

Ready-to-Drink Clenpiq Now Available for Colonoscopy Prep

By February 12, 2018

Clenpiq is indicated for cleansing of the colon as a preparation for colonoscopy in adults.

Recurrent Salmonella enterica Typhimurium infection disables host protection against intestinal inflammation

February 04, 2018

Repeated gastrointestinal infections in mice, in this case Salmonella enterica Typhimurium (ST), caused intestinal tissue inflammation which escalated with repeated infections.

Review: Managing Patients With Refractory Heartburn

By February 01, 2018

Patients with functional heartburn display similar symptoms seen in GERD and most often complain of a burning retrosternal discomfort. Once the underlying cause of a patient's refractory heartburn is determined, appropriate therapy can be initiated.

Ocaliva Prescribing Information Updated to Reinforce Correct Dosing

By February 01, 2018

A table is included in the updated prescribing information to increase the prominence of the recommended Ocaliva dosage by disease stage and Child-Pugh classification.

Efficacy of Linaclotide, Plecanatide Evaluated for CIC, IBS-C Treatment

By January 31, 2018

There was no significant difference between the two therapies in odds ratios for efficacy, diarrhea, or diarrhea-related study withdrawals.

Ulcerative Colitis Treatments

January 31, 2018

Medications for the treatment, induction of remission, and maintenance of ulcerative colitis.

Bowel Cleansers

January 30, 2018

Bowel cleansing products comparison chart (hyperosmotics, isosmotics, isosmotic/stimulant laxative combinations, osmotics) used for colonoscopy preparation.

FDA to Limit Amount of Doses in OTC Antidiarrheal Packages

By January 30, 2018

The FDA will be working with manufacturers to use blister packs or other single-dose packaging in efforts to limit the number of doses in a package.

Antiemetic Treatments

January 30, 2018

Antiemetic treatment chart including drug formulations, strengths, and usual doses for nausea/vomiting.

Firvanq Approved for <i>C. difficile</i>-Associated Diarrhea, <i>S. aureus</i> Colitis

By January 29, 2018

Firvanq oral solution will replace CutisPharma's FIRST-Vancomycin Unit-of-Use Compounding Kit, which was used by pharmacists to compound vancomycin oral liquid.

Obeticholic Acid Monotherapy Leads to Jaundice in PBC Patient

By January 26, 2018

While OCA may be approved as monotherapy for PBC, the authors believe that clinicians should make sure that patients are truly not responding to UDCA before starting treatment.

Trulance Gains New Indication for IBS With Constipation

By January 25, 2018

Apart from a single amino acid substitution, Trulance is structurally identical to human uroguanylin and is thought to replicate the pH-sensitive activity of uroguanylin.

Hyperandrogenism May Impact Gut in Polycystic Ovary Syndrome

January 24, 2018

There was a change in alpha diversity of women with PCOM that was intermediate between the other two groups. Regression analyses revealed a negative correlation of hyperandrogenism, total testosterone, and hirsutism with alpha diversity.

Olmesartan Use Linked to Higher Rate of Enteropathy Compared to Other ARBs

By January 23, 2018

The authors note that while the evidence points to a higher rate of enteropathy outcomes in patients treated with olmesartan, the absolute rate was found to be low.

Swallowable Alternative to Endoscopy for Barrett's Esophagus Detection

January 23, 2018

The researchers found that for discriminating BE-related metaplasia and neoplasia cases versus normal individuals, CCNA1 DNA methylation had an area under the curve of 0.95, which was identical to that of VIM DNA methylation.

Recall: Bottle Labeled as Laxative May Contain NSAID Instead

By January 22, 2018

Distributors have been notified by the company and a return of the Lot is being arranged. Consumers and retailers in possession of Lot #352300 should return the product to Magno-Humphries Laboratories.