Ergotamine tartrate + Caffeine Suppositories Rx

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Ergotamine tartrate + Caffeine Suppositories

Migraine and headache
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Generic Name and Formulations:

Ergotamine tartrate 2mg, caffeine 100mg; rectal supp.

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Indications for Ergotamine tartrate + Caffeine Suppositories:

Migraine, migraine variants, cluster headaches.


1 supp rectally at onset of attack, then 1 supp after 1 hour if needed; max 2 supps/attack, 5 supps/week.


Not recommended.


Peripheral vascular disease. Coronary heart disease. Hypertension. Hepatic or renal dysfunction. Sepsis. Concomitant potent CYP3A4 inhibitors (eg, ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) or other vasoconstrictors. Labor & delivery. Pregnancy (Cat.X).


Monitor for ergotism; do not exceed recommended dose. Nursing mothers: not recommended.

See Also:

Ergotamine tartrate + Caffeine Tablets

Pharmacological Class:

Ergot alkaloid.


See Contraindications. Potentiated by CYP3A4 inhibitors (eg, protease inhibitors, macrolides, azole antifungals, saquinavir, nefazodone, fluoxetine, fluvoxamine, grapefruit juice, zileuton), propranolol, nicotine. Severe hypertension with sympathomimetics.

Adverse Reactions:

Vasoconstrictive complications or ergotism (eg, ischemia, cold extremities, vasospasm, ECG changes, hyper- or hypotension, numbness, gangrene, dizziness), precordial or muscle pain, tachycardia, bradycardia, nausea, vomiting, local edema, itching; rarely: retroperitoneal and pleuropulmonary fibrosis, cardiac valve fibrosis (chronic use).


Formerly known under the brand names Cafergot, Migergot.

How Supplied:

Contact supplier.