Endocrine Disorders

SGLT-2 inhibitors and GLP-1 agonists associated with better mortality outcomes than DPP-4 inhibitors for T2D

April 20, 2018

SGLT-2 or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment.

Artificial Pancreas Treatment Efficacious for Type 1 Diabetes

April 20, 2018

Increased time in the near normoglycemic range and reduced time in hypo- and hyperglycemia

Young Adults With T1DM Show Muscle Metabolic Deficiencies

April 18, 2018

Participants with type 1 diabetes had an increase in the size and number of autophagic remnants in muscles; however, levels of the autophagic regulatory protein, phosphorylated AMP-activated protein kinase, and its downstream targets were similar between groups.

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

April 16, 2018

The researchers found that the prevalence and incidence of DR changed in a similar manner across the distributions of 1h-PG and 2h-PG concentrations.

Soda Tax Cuts Daily Soda, Energy Drink Consumption

April 13, 2018

Compared to the control cities, within the first 2 months of tax implementation the odds of daily consumption in Philadelphia were lower for regular soda (odds ratio, 0.6) and energy drinks (odds ratio, 0.36), while consumption of bottled water was higher (odds ratio, 1.58).

Continuous Glucose Monitoring Cost-Effective in T1DM

April 13, 2018

A total of 158 patients with T1D and hemoglobin A1c (HbA1c) ≥7.5% were randomized in a 2:1 ratio to CGM versus control.

Pharmacists Can Help With Diabetes Management Via Telemedicine

April 13, 2018

Telemedicine could improve the situation of avoiding adverse events and ensuring proper day-to-day dosing by providing a real-time feedback loop, allowing clinical pharmacists to track data in real time.

Canagliflozin May Improve Renal Outcomes in Patients With T2D

By April 12, 2018

The renal protective benefit was seen in patients with both reduced (eGFR <60mL/min/1.73m2) and preserved (eGFR ≥60mL/min/1.73m2) renal function.

Higher Mortality Risk Seen for 'Night Owls'

April 12, 2018

Data were included in the study for 433,268 adults aged 38 to 73 years at the time of enrollment, who were followed for an average of 6.5 years.

FDA Approves Unique Device for Diabetic Retinopathy Screening

By April 11, 2018

This is the first device authorized for marketing that provides a screening decision without the need for clinician interpretation.

No Reduced CVD Risk for SBP &#60;120mmHg in Type 2 Diabetes

April 11, 2018

"Our findings support a SBP treatment target of 140mmHg and suspect no risk reduction attenuation on CVD for lower SBP targets," the authors write.

AUA: New Guidelines for Diagnosis, Management of Testosterone Deficiency

By April 10, 2018

Clinicians should use a total testosterone level below 300ng/dL as a reasonable cut-off in support of the diagnosis of low testosterone.

Eating Pecans May Cut Risk of Cardiovascular Disease, Diabetes

April 09, 2018

The researchers found that after 4 weeks on a pecan-rich diet, changes in serum insulin and homeostatic model assessment of insulin resistance and beta cell function were significantly greater compared to the control diet (P<0.05).

Lactation Lowers Risk of T2DM After Gestational Diabetes

April 05, 2018

By pooling data from three studies, long-term lactation (more than 1 to 3 months postpartum) was not associated with T2DM risk compared with no lactation (relative risk, 0.69; 95% confidence interval, 0.41 to 1.17).

Bydureon Single Dose Trays to Be Discontinued

By April 04, 2018

The 2mg Single Dose Tray presentation will be permanently discontinued on September 30, 2018.

Diabetes Treatments

April 04, 2018

Antidiabetic agents for the treatment of diabetes including maintenance and max doses.

Bydureon Approved for Use With Basal Insulin for Uncontrolled T2D

By April 03, 2018

The DURATION-7 study examined the effect of Bydureon or placebo as add-on therapy to insulin glargine, with or without metformin, in adults with T2D.

Thyroidectomy Rates Lower After Guideline Implementation

April 02, 2018

Researchers found that up-front total thyroidectomy was performed in 61% of patients before the 2015 American Thyroid Association guidelines were implemented and in 31.4% after guideline implementation (odds ratio [OR], 0.29).

Islet Transplantation Improves Quality of Life in T1DM

March 29, 2018

There were also significant reductions in the Hypoglycemic Fear Survey total score and its two subscales (all P<0.0001) across all time points.

Add-On Antihypertensives Compared in Patients With Diabetes on ACEIs, ARBs

By March 28, 2018

The composite significant kidney event end point was defined as the first occurrence of ≥30% decline in eGFR to an eGFR <60mL/min/1.73m2, initiation of dialysis or kidney transplant.

Diagnosing Diabetes: How Much Did it Cost in 2017?

March 28, 2018

The average medical expenditures were ~$16,750 per year for people with diagnosed diabetes, with ~$9,600 attributed to diabetes. On average, people with diagnosed diabetes had medical expenditures about 2.3 times higher than expected in the absence of diabetes.

Dexcom G6 Integrated Continuous Glucose Monitoring System Gets FDA Approval

By March 27, 2018

The Dexcom G6 iCGM system determines blood glucose levels in patients 2 years of age and older.

Metformin Use Linked to Reduced Risk of Statin-Associated Muscle Pain

By March 27, 2018

Statin-associated muscle pain can hinder medication adherence which could potentially lead to an increased risk of cardiovascular events.

Toujeo Max SoloStar Gets FDA Approval for Patients With Diabetes

By March 27, 2018

Sanofi announced that the Food and Drug Administration (FDA) has approved Toujeo (insulin glargine 300 Units/mL) Max SoloStar, a long-acting insulin pen that holds 900 Units of Toujeo and provides up to 160 Units/mL per injection.

Case Report Reveals Another Possible Side Effect of Kratom

By March 26, 2018

According to the authors, this is the first report of kratom-induced hyperprolactinemia.

Tresiba Label Updated With Data on Severe Hypoglycemia, CV Outcomes

By March 26, 2018

The Tresiba label was updated to reflect safety outcomes from the DEVOTE trial.

Sotagliflozin NDA Submitted to FDA for Type 1 Diabetes

By March 26, 2018

Sotagliflozin is an investigational dual sodium-glucose co-transporter types 1 and 2 (SGLT1, SGLT2) inhibitor.

Food Insecurity Tied to Poor Glycemic Control in Diabetes

March 23, 2018

Food insecurity was correlated with increased HbA1c (difference, 0.6%) in adjusted models, which did not improve over time. Living in an area with low physical food access was not linked to a difference in HbA1c or with change over time.

Implantable Sensor Relays Real-Time Personal Health Info

March 22, 2018

The researchers described the use of functionalized soft, porous hydrogel scaffolds with luminescent chemistries and demonstrated their functionality in the body for over 4 years.

Oxyntomodulin Effects on Insulin Secretory Rates, Glycemic Excursion Evaluated

March 21, 2018

The effects of an intravenous infusion of native OXM on insulin secretory rates and glycemic excursion were assessed in a graded glucose infusion GGI procedure in 2 separate placebo-controlled trials in 12 overweight and obese subjects without diabetes and in 12 obese subjects with T2DM.