Endocrine Disorders

Androgens

December 11, 2018

Androgens used for testosterone replacement therapy organized by route of administration chart.

Insulins

December 11, 2018

Types of insulins categorized by their pharmacodynamic properties.

Hypothyroidism Treatment No Longer Available

By December 07, 2018

The manufacturing discontinuation was a business decision made by the Company.

Type 2 Diabetes Linked to Colorectal Cancer Risk in Men

December 06, 2018

Significant association for men, with positive but not statistically significant link seen for women

Can liraglutide reduce risk for major cardiac events in elderly diabetics?

December 05, 2018

Type 2 diabetes mellitus continues to increase in prevalence among older adults, with significant associated morbidity and mortality. The authors of this study examined the cardiovascular effects of liraglutide compared to placebo in older patients.

Glycemic Control, Weight Changes, Hypoglycemia Risk: Diabetes Drugs Compared

By December 04, 2018

Important similarities and differences of 6 non-insulin antihyperglycemic drug classes were highlighted in a recently published meta-analysis.

Cost-Related Insulin Underuse May Affect 1 in 4 Patients

December 04, 2018

About 1 in 4 patients report cost-related insulin underuse, which is associated with poor glycemic control.

Impact of Fructose Varies With Energy Control, Food Source

December 03, 2018

The researchers found that in substitution or subtraction studies, total fructose-containing sugars had no harmful effect on any outcome, with a decrease in hemoglobin A1c in substitution studies (mean difference, −0.22%).

Certain SGLT2 Inhibitors, GLP-1 RAs for T2DM Also Cut CV Risk

November 30, 2018

Report provides guidance on reducing CV risk in patients with T2DM and atherosclerotic CV disease

Climate Change Ups Heat Deaths, Especially Among Elderly

November 30, 2018

Last year, 157 million at-risk people were exposed to heat waves worldwide; 18 million more than in 2016.

Xyosted Now Available for Treatment of Testosterone Deficiency

By November 29, 2018

Prior to starting Xyosted, the patient's baseline cardiovascular risk should be considered and blood pressure should be adequately controlled.

Insulin Needed for T2DM Tx Set to Increase More Than 20% by 2030

November 26, 2018

Using higher HbA1c target in over-75s could increase disability-adjusted life-years by 44.2 percent

Diabetes patients with high-deductible care plans may delay seeking crucial care

November 20, 2018

Many Americans have "high-deductible" health insurance policies, which involves plans that require them to pay up to $7000 out-of-pocket annually if they utilize health care services.

Serious Adverse Events Compared With SGLT2 Inhibitors, GLP1 Receptor Agonists

November 16, 2018

Risk increased for lower-limb amputation, diabetic ketoacidosis compared with GLP1 receptor agonists

CDC: Many Americans May Have Prediabetes and Not Know It

November 16, 2018

More than one-third of Americans have prediabetes, but 90% of them do not know they have it, medical experts say.

Dapagliflozin May Lower Heart Failure Hospitalizations in Patients With Diabetes

November 14, 2018

Dapagliflozin was not associated with either a higher or lower rate of MACE compared with placebo in patients with type 2 diabetes who had or were at risk for atherosclerotic cardiovascular disease.

Can a Physician Be Assessed Punitive Damages for Altering or Destroying Medical Records?

By November 13, 2018

During her testimony, Dr E was asked about the notes in the chart, and she was forced to admit that she transcribed the scribble notes into the patient's record after the patient died and she had been contacted by the plaintiff's law firm asking for the records.

Direct-Acting Antiviral Therapy Linked to Reduced Risk of Incident T2D in HCV Patients

By November 13, 2018

The study compared US administrative claims data of HCV patients with ≥12 weeks of dispensed DAA therapy (N=17,848) to untreated HCV patients with follow-up data (N=108,350).

Empagliflozin Effectively Reduces Risk for Heart Failure Hospitalization

November 11, 2018

Approximately 50% of deaths in people with type 2 diabetes worldwide, and approximately two-thirds of deaths in people with type 2 diabetes in the US are caused by cardiovascular disease.

CDC: About One in Three Adults With Prediabetes Has Arthritis

November 09, 2018

The unadjusted prevalence rates of leisure-time physical inactivity and obesity were 56.5 and 50.1%, respectively, among adults with both arthritis and prediabetes.

Hypoglycemia Following Antifungal Tx in Patient With Type 1 Diabetes

By November 07, 2018

"This is the first report of decreased insulin requirements in a patient with T1DM correlating with micafungin administration," noted the authors.

New Single-Vial Formulation of Egrifta Approved to Treat Excess HIV-Related VAT

By November 06, 2018

The new "F4" formulation is 4 times more concentrated than the version currently available on the market.

Aggressive Control of BP, Lipids in T2DM May Up Kidney Risk

November 02, 2018

"We believe that the data actually suggest possible benefit for ESKD [end-stage kidney disease] with intensive glucose control, and remain inconclusive for intensive blood pressure control and fibrate use given the wide confidence intervals for the more reliable ESKD outcomes," write the authors.

Plant-Based Diets Better for T2D Than Several Official Diabetes Guidelines

November 02, 2018

Researchers found that, compared with several diabetes associations' official guidelines and other comparator diets, plant-based diets were correlated with significant improvements in emotional well-being, physical well-being, depression, and quality of life.

Invokana Approved to Reduce Risk of Major Adverse Cardiovascular Events

By October 30, 2018

The effect of Invokana on CV risk was evaluated in the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in >10,000 adults with T2D who had established CV disease or were at risk for CV disease with ≥2 risk factors.

Ready-to-Use Glucagon Rescue Pen Under FDA Review for Severe Hypoglycemia Tx

By October 23, 2018

The NDA included findings from multiple Phase 3 trials evaluating the safety, efficacy, and utility of the Xeris glucagon rescue pen auto-injector to treat severe hypoglycemia vs currently available glucagon emergency kits in children, adolescents, and adults with type 1 diabetes.

Saxenda Labeling Updated With Cardiovascular Safety Data

By October 23, 2018

The randomized, double-blind, placebo-controlled, parallel-group study (N=9340) evaluated the time from randomization to first occurrence of major adverse CV events (MACE) (non-fatal heart attack, non-fatal stroke, CV death) in patients treated with liraglutide 1.8mg once daily or placebo.

Abatacept May Reduce Diabetes Risk in Rheumatoid Arthritis

October 23, 2018

The researchers concluded their findings indicate that for patients with RA, abatacept reduced the risk for diabetes and "potentially improved insulin sensitivity and glycemic profile."

Gastric Banding, Metformin Assessed for Glycemia Improvements

October 16, 2018

The researchers found that at 24 months, the band group lost 10.7kg and the metformin group lost 1.7kg (P<.01). Furthermore, in the band group, insulin sensitivity increased 45% compared with 25% in the metformin group (P=.3 between groups).

Cases Show Periodic Fasting May Cut Medication Use in T2DM

October 15, 2018

Discontinuation of insulin, other diabetes medications seen in case series of three patients