Endocrine Disorders

Ertugliflozin Beneficial for Patients With Inadequately Controlled T2DM

February 20, 2018

The researchers found that the mean change in glycated hemoglobin (HbA1c) from baseline to week 52 was −0.9 and −1% in the ertugliflozin 5- and 15-mg groups, respectively; the proportion of patients with HbA1c <7% was 25.6 and 28.5%, respectively, at week 52

Availability of Decadron Tablets Announced

By February 16, 2018

Decadron is a first-generation adrenocortical steroid.

Sudden Cardiac Arrest, Ventricular Arrhythmia Risk Examined With Sulfonylureas

By February 16, 2018

Using U.S. Medicaid claims (1999-2010) from 5 states, the researchers sought to examine the association between individual sulfonylureas (glyburide, glimepiride, glipizide) and outpatient-originating SCA/VA; glipizide exposure was considered the reference exposure.

Ready-to-Use Rescue Pen for Severe Hypoglycemia Moves Closer to Approval

By February 16, 2018

The full findings of the trials will not be released until later this year however the Company stated that the trials were a success, with the data already shared with the FDA in a pre-New Drug Application (NDA) meeting.

Factors Leading to Diabetes May Be Identified 20 Years Before Diagnosis

February 12, 2018

A total of 28,244 new T2D cases were identified over the study period, yielding an average 20-year risk of 8.1%. Overweight and obese subjects and those with elevated fasting glucose (fGlu) and triglycerides (TG) had a substantially increased risk among both men and women.

Ozempic, Fiasp Now Available for the Treatment of Diabetes

By February 05, 2018

Both medications received approval from the FDA in 2017.

Improved islet encapsulation device for the treatment of type 1 diabetes

February 05, 2018

A device for islet transplantation for type 1 diabetes was designed and demonstrated to be safe and retrievable in animal models.

Zomacton Approved to Treat Growth Hormone Deficiency in Adults

By February 01, 2018

Zomacton now approved for replacement of endogenous GH in adults with GH deficiency.

Semaglutide Goes Head-to-Head With Dulaglutide in Type 2 Diabetes Trial

By February 01, 2018

The overall safety profiles of semaglutide and dulaglutide were similar in SUSTAIN 7.

Diabetes Treatments

February 01, 2018

Antidiabetic agents for the treatment of diabetes including maintenance and max doses chart.

Disordered Eating Behavior Linked to Higher HbA1c in Type 1 Diabetes

January 31, 2018

Youth with DEBs had poor glycemic control at baseline that persisted through study. A significant DEB × time interaction effect was seen for mean sensor glucose (P=0.05) and percent sensor glucose values >180mg/dL (P=0.04).

Intranasal Acromegaly Treatment Gains Orphan Drug Designation

By January 30, 2018

Octreotide is a somatostatin analog that suppresses excessive growth hormone production from pituitary adenomas.

Diet Soda Independently Linked to Higher Diabetic Retinopathy Risk

January 30, 2018

Compared to those with no diet soft drink consumption, there was an independent association between high diet soft drink consumption and increased likelihood of having PDR (odds ratio, 2.51).

Glucagon May Not be Fully Utilized in Prehospital, Emergency Settings

January 30, 2018

Noting that there are 198,200 providers of basic emergency medicine compared with 61,121 paramedics (who are the only members of EMS who carry and administer glucagon), 3 out of 4 times the dispatched responder may be unable to treat hypoglycemia with glucagon.

Update Regarding Tanzeum Injection Availability

By January 26, 2018

The initial decision to discontinue Tanzeum was announced in August 2017 due to limited prescribing of the drug.

Occupational Therapy Beneficial for Young Adults With Diabetes

January 26, 2018

The effect was not modified significantly by sex, ethnicity, diabetes type, recruitment site, or socioeconomic status.

Patients With Diabetes May Be at Increased Risk for Serious Infection

January 24, 2018

Findings demonstrate an important population burden, including hospitalization and death

First trimester exposure to antithyroid drugs associated with increased risk of birth defects

January 23, 2018

First trimester exposure to anytithyroid drugs (ATDs) was associated with a greater risk of congenital malformations, especially for pregnant women who were given prescriptions for methimazole (MMI) or both MMI and propylthiouracil (PTU).

Antithyroid Drug Exposure in Early Pregnancy May Up the Risk for Congenital Malformations

January 23, 2018

The prevalence of malformations was 7.27 versus 5.94% in exposed offspring versus offspring of women who were not prescribed ATDs during pregnancy.

NovoFine 30G 8mm Pen Needle Will Soon Be Unavailable

By January 22, 2018

The NovoFine Plus 32G 4mm is recommended in its place for appropriate patients.

Growth hormone releasing hormone (GHRH) agonists protect against diabetic retinopathy in animal model

January 19, 2018

GHRH and GHRH receptor levels are decreased in diabetic rats and humans.

Noninvasive Marker May ID Severity of Diabetic Retinopathy

January 18, 2018

"Further longitudinal studies seem warranted to determine whether DRIL is a clinically relevant noninvasive morphological marker in eyes with DME," the authors write.

Iodine Deficiency May Impact Fertility in Women of Childbearing Age

January 16, 2018

Those with moderate-to-severe deficiency (iodine-creatinine ratios <50 μg/g) had a 46% reduction in fecundity versus those whose iodine-creatinine ratios were in the adequate range (adjusted fecundability odds ratio of becoming pregnant per cycle, 0.54).

FDA Committee Votes on New Oral Testosterone Replacement Tx

By January 11, 2018

The FDA's Bone, Reproductive and Urologic Drugs Advisory Committee (BRUDAC) voted 6 in favor and 13 against the benefit/risk profile of Tlando (testosterone undecanoate) capsules.

Bydureon BCise Now Available for the Treatment of Type 2 Diabetes

By January 10, 2018

Bydrueon BCise is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Unstable Housing Correlated to Increase in Diabetes-Related ER Visits

January 10, 2018

The researchers found that 13.7% of participants reported a diabetes-related emergency department visit or hospitalization in the previous 12 months.

Ibuprofen Use Linked to Compensated Hypogonadism in Males

By January 09, 2018

For short term ibuprofen use the effects of compensated hypogonadism are reversible, however the researchers state how it is unknown whether these effects are reversible for long-term ibuprofen use.

Bidirectional Links Between Depression, Severe Dysglycemia Evaluated in T1D

January 05, 2018

Depression was strongly associated with increased risk of severe hyperglycemic and hypoglycemic events.

Experts Weigh In on the Best Diets for 2018

By January 03, 2018

DASH and the Mediterranean diet also tied for top stop in the 'Best Diets for Healthy Eating' category will DASH ranked number 1 for the 'Best Heart-Healthy Diets'.

Safety, Tolerability of Dasiglucagon Examined for Severe Hypoglycemia

January 03, 2018

Early pharmacodynamic response for Dasiglucagon were similar to that of GlucaGen, with longer lasting effects plasma glucose.