Selegiline Rx

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Generic Name and Formulations:

Selegiline HCl 5mg; caps.

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Indications for Selegiline:

Adjunct to levodopa/carbidopa in Parkinsonism.


5mg at breakfast and at lunch; max 10mg/day. After 2–3 days, levodopa/carbidopa dosage may be reduced by 10–30%; further reductions may be possible later.


Not established.


Concomitant meperidine, possibly other opioids.


Selectivity for MAO type B diminishes at doses over 10mg/day. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

MAO-B inhibitor.


See Contraindications. Avoid concomitant tricyclic antidepressants or selective serotonin reuptake inhibitors (SSRIs). Allow at least 5 weeks (or more if used chronically or at high doses) between fluoxetine discontinuance and 2 weeks between paroxetine or sertraline discontinuance before starting selegiline; allow 2 weeks between selegiline discontinuance before starting tricyclic antidepressants or SSRIs. Caution with tyramine-containing foods and with sympathomimetics.

Adverse Reactions:

Nausea, dizziness, lightheadedness, syncope, abdominal pain, confusion, vivid dreams, hallucinations, dry mouth, headache.


Formerly known under the brand name Eldepryl.

How Supplied:

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