Xenon Gas for Inhalation Therapy Gets Fast-Tracked for Post-Cardiac Arrest Syndrome

Xenon, a noble gas, works by inhibiting the N-methyl-D-aspartate receptors
Xenon, a noble gas, works by inhibiting the N-methyl-D-aspartate receptors

Mallinckrodt and NPXe Limited announced that the Food and Drug Administration (FDA) has granted Fast Track designation to xenon gas for inhalation for use in post-cardiac arrest patients. 

Xenon gas for inhalation is an investigational agent set to undergo a Phase 3 trial in the coming months. Xenon, a noble gas, works by inhibiting the N-methyl-D-aspartate receptors (NMDAR), which are overactivated in post-cardiac arrest syndrome, through a unique glycine-binding mechanism; this helps moderate the flow of damaging ions through the calcium channel. Treatment with xenon may improve functional outcomes and reduce mortality in cardiac arrest survivors. 

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"We look forward to the upcoming start of the Phase 3 trial and learning more about this potential therapeutic option in a population of resuscitated cardiac arrest patients," said Steven Romano, MD, Executive Vice President and Chief Scientific Officer at Mallinckrodt.

For more information visit Mallinckrodt.com.