Indications for ZYPITAMAG:

Adjunct to diet to reduce elevated total-C, LDL-C, ApoB, and TG, and to increase HDL-C in primary hyperlipidemia and mixed dyslipidemia.

Limitations of Use:

Effect on cardiovascular morbidity and mortality has not been determined.


Individualize. Initially 2mg once daily; may increase after 4 weeks to max 4mg once daily. Moderate to severe renal impairment (CrCl 15–59mL/min, or ESRD with hemodialysis): initially 1mg once daily; max 2mg once daily. Concomitant erythromycin: max 1mg daily. Concomitant rifampin: max 2mg daily.


Not established.


Active liver disease. Unexplained, persistent elevated serum transaminases. Concomitant cyclosporine. Pregnancy. Nursing mothers.


Increased risk of myopathy and rhabdomyolysis esp. in renal impairment, uncontrolled hypothyroidism, age ≥65yrs, higher dose. Discontinue if markedly elevated CK levels occur or myopathy is confirmed or suspected; suspend if a predisposition to development of renal failure secondary to rhabdomyolysis develops. Immune-mediated necrotizing myopathy; monitor. Monitor liver function prior to initiation and as clinically indicated. Discontinue immediately if serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs. Substantial alcohol ingestion. Advise females of reproductive potential to use effective contraception during treatment.

Pharmacologic Class:

HMG-CoA reductase inhibitor.


See Contraindications. Avoid gemfibrozil. Potentiated by erythromycin, rifampin (see Adults). Increased risk of myopathy with concomitant fibrates, colchicine, niacin (≥1g/day); consider risk/benefit.

Adverse Reactions:

Myalgia, back/extremity pain, diarrhea, constipation; myopathy, rhabdomyolysis, increases in CK, liver enzymes, HbA1c and fasting serum glucose; rare: cognitive impairment, fatal/non-fatal hepatic failure.

Generic Availability:


How Supplied:

Tabs—30, 90, 100, 500, 1000

Pricing for ZYPITAMAG

2mg tablet (Qty: 30)
Appx. price $247