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Zyloprim Generic Name & Formulations
Legal Class
Rx
General Description
Allopurinol 100mg, 300mg; scored tabs.
Pharmacological Class
Xanthine oxidase inhibitor.
How Supplied
100mg—100; 300mg—100, 500
Manufacturer
Zyloprim Indications
Indications
Gout.
Zyloprim Dosage and Administration
Adult
Take with food. Initially 100mg daily. Maintain prophylactic therapy initially. Increase by 100mg daily increments at weekly intervals; max 800mg/day and 300mg/dose. Usual range: mild: 200–300mg daily; severe: 400–600mg daily.
Children
Not recommended.
Zyloprim Contraindications
Not Applicable
Zyloprim Boxed Warnings
Not Applicable
Zyloprim Warnings/Precautions
Warnings/Precautions
Discontinue at 1st sign of skin rash. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy. Nursing mothers.
Zyloprim Pharmacokinetics
See Literature
Zyloprim Interactions
Interactions
Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.
Zyloprim Adverse Reactions
Adverse Reactions
Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, SJS, DRESS, generalized vasculitis), renal failure.
Zyloprim Clinical Trials
See Literature
Zyloprim Note
Not Applicable
Zyloprim Patient Counseling
See Literature
Zyloprim Generic Name & Formulations
Legal Class
Rx
General Description
Allopurinol 100mg, 300mg; scored tabs.
Pharmacological Class
Xanthine oxidase inhibitor.
How Supplied
100mg—100; 300mg—100, 500
Manufacturer
Zyloprim Indications
Indications
Hyperuricosuria and hyperuricemia induced nephropathy due to cancer chemotherapy.
Zyloprim Dosage and Administration
Adult
600–800mg daily for 2–3 days with fluids.
Children
Not recommended.
Zyloprim Contraindications
Not Applicable
Zyloprim Boxed Warnings
Not Applicable
Zyloprim Warnings/Precautions
Warnings/Precautions
Discontinue at 1st sign of skin rash. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy. Nursing mothers.
Zyloprim Pharmacokinetics
See Literature
Zyloprim Interactions
Interactions
Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.
Zyloprim Adverse Reactions
Adverse Reactions
Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, SJS, DRESS, generalized vasculitis), renal failure.
Zyloprim Clinical Trials
See Literature
Zyloprim Note
Not Applicable
Zyloprim Patient Counseling
See Literature
Zyloprim Generic Name & Formulations
Legal Class
Rx
General Description
Allopurinol 100mg, 300mg; scored tabs.
Pharmacological Class
Xanthine oxidase inhibitor.
How Supplied
100mg—100; 300mg—100, 500
Manufacturer
Zyloprim Indications
Indications
Management of recurrent calcium oxalate calculi in hyperuricosurics. Hyperuricosuria and hyperuricemia induced nephropathy due to cancer chemotherapy.
Zyloprim Dosage and Administration
Adult
Take with food. Calculi: 200–300mg daily. Adjust based on urinary urate levels. Chemotherapy-induced nephropathy prophylaxis: 600–800mg daily for 2–3 days with fluids.
Children
Usually not recommended. Chemotherapy–induced nephropathy prophylaxis: <6yrs: 150mg daily. 6–10yrs: 300mg daily.
Zyloprim Contraindications
Not Applicable
Zyloprim Boxed Warnings
Not Applicable
Zyloprim Warnings/Precautions
Warnings/Precautions
Discontinue if rash occurs. Use only if daily uric acid excretion exceeds 800mg in males or 750mg in females. Advise reduction of animal protein, sodium, refined sugars, oxalate-rich foods, and excessive calcium intake. Increase fiber intake. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy (Cat.C). Nursing mothers.
Zyloprim Pharmacokinetics
See Literature
Zyloprim Interactions
Interactions
Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.
Zyloprim Adverse Reactions
Adverse Reactions
Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, SJS, DRESS, generalized vasculitis), renal failure.
Zyloprim Clinical Trials
See Literature
Zyloprim Note
Not Applicable
Zyloprim Patient Counseling
See Literature
