Zylet Generic Name & Formulations
Loteprednol etabonate 0.5% + tobramycin 0.3%, oph susp; contains benzalkonium chloride.
Steroid + aminoglycoside.
Ocular inflammation associated with infection or risk thereof.
Zylet Dosage and Administration
Instill 1–2 drops into the conjunctival sac of affected eye(s) every 4–6hrs; may increase to every 1–2hrs in first 24–48hrs; reduce dose as symptoms improve; max 20mL for first ℞. Reevaluate if no improvement after 2 days.
Ocular fungal, viral, or mycobacterial infections.
Zylet Boxed Warnings
Corneal or scleral thinning. Glaucoma. Monitor IOP and for secondary infections and for cataracts in prolonged use (>10 days). Monitor blood levels in combined aminoglycoside therapy. Avoid abrupt cessation. Soft contact lenses (remove during therapy). Pregnancy. Nursing mothers.
Zylet Adverse Reactions
Secondary ocular infections, injection, superficial punctate keratitis, increased IOP, ocular discomfort (eg, burning, stinging, itching, discharge) visual/lacrimation/eyelid disorder, photophobia, corneal deposits, headache. May mask or exacerbate ocular infections. May delay wound healing and increase bleb formation after cataract surgery. In prolonged use: increased IOP, optic nerve damage, cataract formation, corneal perforation.
Zylet Clinical Trials
Zylet Patient Counseling