Zyflo Cr

  • Asthma/COPD

Zyflo Cr Generic Name & Formulations

General Description

Zileuton 600mg; ext-rel tabs.

Pharmacological Class

5-lipoxygenase inhibitor.

See Also

How Supplied

Tabs, CR tabs—120


Generic Availability


Zyflo Cr Indications


Prophylaxis and chronic treatment of asthma.

Zyflo Cr Dosage and Administration


Swallow whole. Take within 1hr after morning and evening meals. 1200mg twice daily; max: 2400mg/day.


<12yrs: not recommended.

Zyflo Cr Contraindications


Active liver disease. Persistent ALT elevations ≥3xULN.

Zyflo Cr Boxed Warnings

Not Applicable

Zyflo Cr Warnings/Precautions


Not for primary treatment of acute attacks. Monitor liver function before initiating therapy, monthly for the 1st 3 months, every 2–3 months for the remainder of the year, and periodically thereafter (discontinue if signs/symptoms occur). History of liver disease. Alcohol consumption. Evaluate if neuropsychiatric events occur. Pregnancy (Cat.C). Nursing mothers: not recommended.

Zyflo Cr Pharmacokinetics

See Literature

Zyflo Cr Interactions


Potentiates theophylline (reduce dose of theophylline by about ½). Potentiates warfarin, propranolol (possibly other β-blockers); monitor and adjust doses. Monitor concomitant CYP3A4 inhibitors (eg, ketoconazole).

Zyflo Cr Adverse Reactions

Adverse Reactions

Sinusitis, pharyngolaryngeal pain, abdominal pain, nausea, dyspepsia, headache, rash, hypersensitivity, hepatotoxicity, upper respiratory tract infection, myalgia; neuropsychiatric events (eg, sleep disorders, behavior changes).

Zyflo Cr Clinical Trials

See Literature

Zyflo Cr Note

Not Applicable

Zyflo Cr Patient Counseling

See Literature