Indications for: ZYFLO CR

Prophylaxis and chronic treatment of asthma.

Adult Dosage:

Swallow whole. Take within 1hr after morning and evening meals. 1200mg twice daily; max: 2400mg/day.

Children Dosage:

<12yrs: not recommended.

ZYFLO CR Contraindications:

Active liver disease. Persistent ALT elevations ≥3xULN.

ZYFLO CR Warnings/Precautions:

Not for primary treatment of acute attacks. Monitor liver function before initiating therapy, monthly for the 1st 3 months, every 2–3 months for the remainder of the year, and periodically thereafter (discontinue if signs/symptoms occur). History of liver disease. Alcohol consumption. Evaluate if neuropsychiatric events occur. Pregnancy (Cat.C). Nursing mothers: not recommended.

See Also:

ZYFLO CR Classification:

5-lipoxygenase inhibitor.

ZYFLO CR Interactions:

Potentiates theophylline (reduce dose of theophylline by about ½). Potentiates warfarin, propranolol (possibly other β-blockers); monitor and adjust doses. Monitor concomitant CYP3A4 inhibitors (eg, ketoconazole).

Adverse Reactions:

Sinusitis, pharyngolaryngeal pain, abdominal pain, nausea, dyspepsia, headache, rash, hypersensitivity, hepatotoxicity, upper respiratory tract infection, myalgia; neuropsychiatric events (eg, sleep disorders, behavior changes).

Generic Drug Availability:


How Supplied:

Tabs, CR tabs—120

Pricing for ZYFLO CR

600mg tablet (Qty: 120)
Appx. price $1082