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Zoryve Generic Name & Formulations
Legal Class
Rx
General Description
Roflumilast 0.3%; crm.
Pharmacological Class
Phosphodiesterase 4 (PDE4) inhibitor.
How Supplied
Crm—60g
Manufacturer
Generic Availability
NO
Zoryve Indications
Indications
Plaque psoriasis, including intertriginous areas.
Zoryve Dosage and Administration
Adult
Apply to the affected area(s) once daily; rub in completely.
Children
<12yrs: not established.
Zoryve Contraindications
Contraindications
Moderate to severe liver impairment (Child-Pugh B or C).
Zoryve Boxed Warnings
Not Applicable
Zoryve Warnings/Precautions
Warnings/Precautions
Not for oral, ophthalmic, or intravaginal use. Labor & delivery: not recommended. Pregnancy. Nursing mothers: avoid direct infant exposure.
Zoryve Pharmacokinetics
See Literature
Zoryve Interactions
Interactions
May be potentiated by systemic CYP3A4 inhibitors, dual CYP3A4/CYP1A2 inhibitors (eg, erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine), oral contraceptives containing gestodene + ethinyl estradiol; consider risks vs benefits prior to concomitant use.
Zoryve Adverse Reactions
Adverse Reactions
Diarrhea, headache, insomnia, application site pain, upper respiratory tract infections, urinary tract infections.
Zoryve Clinical Trials
See Literature
Zoryve Note
Not Applicable
Zoryve Patient Counseling
See Literature
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