Zoryve

— THERAPEUTIC CATEGORIES —
  • Psoriasis

Zoryve Generic Name & Formulations

General Description

Roflumilast 0.3%; crm.

Pharmacological Class

Phosphodiesterase 4 (PDE4) inhibitor.

How Supplied

Crm—60g

Generic Availability

NO

Zoryve Indications

Indications

Plaque psoriasis, including intertriginous areas.

Zoryve Dosage and Administration

Adult

Apply to the affected area(s) once daily; rub in completely.

Children

<12yrs: not established.

Zoryve Contraindications

Contraindications

Moderate to severe liver impairment (Child-Pugh B or C).

Zoryve Boxed Warnings

Not Applicable

Zoryve Warnings/Precautions

Warnings/Precautions

Not for oral, ophthalmic, or intravaginal use. Labor & delivery: not recommended. Pregnancy. Nursing mothers: avoid direct infant exposure.

Zoryve Pharmacokinetics

See Literature

Zoryve Interactions

Interactions

May be potentiated by systemic CYP3A4 inhibitors, dual CYP3A4/CYP1A2 inhibitors (eg, erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine), oral contraceptives containing gestodene + ethinyl estradiol; consider risks vs benefits prior to concomitant use.

Zoryve Adverse Reactions

Adverse Reactions

Diarrhea, headache, insomnia, application site pain, upper respiratory tract infections, urinary tract infections.

Zoryve Clinical Trials

See Literature

Zoryve Note

Not Applicable

Zoryve Patient Counseling

See Literature

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