• Colorectal disorders

Zorbtive Generic Name & Formulations

General Description

Somatropin (rDNA origin) 8.8mg; per vial; lyophilized pwd for SC inj after reconstitution; diluent contains benzyl alcohol.

Pharmacological Class

Growth hormone (GH).

How Supplied

Vials—1 (w. diluent)


Zorbtive Indications


Short bowel syndrome in conjunction with nutritional support (see full labeling).

Zorbtive Dosage and Administration


Rotate inj site. Initially 0.1mg/kg SC inj once daily; max 8mg/day. Treat for 4 weeks. If fluid retention or arthralgia occurs; reduce dose by 50%. Discontinue therapy for up to 5 days if severe toxicities occur; if resolved, resume at 50% of original dose; if unresolved within 5 days or recurs, discontinue permanently.


Not established.

Zorbtive Contraindications


Active malignancy. Acute critical illness due to complications following open heart or abdominal surgery, multiple accidental trauma, or acute respiratory failure. Active proliferative or severe non-proliferative diabetic retinopathy.

Zorbtive Boxed Warnings

Not Applicable

Zorbtive Warnings/Precautions


Monitor for potential malignant changes of preexisting nevi. Increased mortality in those with acute critical illness (see Contraindications). Impaired glucose tolerance/diabetes mellitus: monitor blood glucose. Hypoadrenalism: monitor serum cortisol levels. Evaluate thyroid function in those with hypopituitarism before starting and after 4 weeks treatment; correct thyroid function, if needed. Perform funduscopic evaluation for intracranial hypertension at initiation; discontinue if papilledema occurs. Elderly. Pregnancy. Nursing mothers.

Zorbtive Pharmacokinetics

See Literature

Zorbtive Interactions


May antagonize glucocorticoids. Concomitant antidiabetic treatment may need to be adjusted.

Zorbtive Adverse Reactions

Adverse Reactions

Edema (eg, facial, peripheral), arthralgia, inj site pain, flatulence, abdominal pain, vomiting, pain, nausea; hypersensitivity reactions, tissue turgor (swelling in hands/feet), musculoskeletal discomfort, carpal tunnel syndrome (reduce dose or discontinue if unresolved), acute pancreatitis.

Zorbtive Clinical Trials

See Literature

Zorbtive Note

Not Applicable

Zorbtive Patient Counseling

See Literature