• Thromboembolic disorders

Zontivity Generic Name & Formulations

General Description

Vorapaxar 2.08mg (equivalent to 2.5mg of vorapaxar sulfate); tabs.

Pharmacological Class

Protease-activated receptor-1 (PAR-1) antagonist.

How Supplied

Tabs—30, 90


Generic Availability


Zontivity Indications


To reduce thrombotic cardiovascular events in patients with a history of myocardial infarction or with peripheral arterial disease.

Zontivity Dosage and Administration


2.08mg once daily. Use with aspirin and/or clopidogrel according to their indications or standard of care.


Not established.

Zontivity Contraindications


History of stroke, transient ischemic attack (TIA), or intracranial hemorrhage (ICH). Active pathological bleeding (eg, peptic ulcer, ICH).

Zontivity Boxed Warnings

Boxed Warning

Bleeding risk.

Zontivity Warnings/Precautions


Discontinue if stroke, TIA, or ICH occurs. Increased risk of bleeding (may be fatal). Consider underlying risk of bleeding before initiating (eg, older age, low body wt., reduced renal or hepatic function, history of bleeding disorders, concomitant certain medications). Hypotensive and has recently undergone coronary angiography, PCI, CABG or other surgeries: suspect bleeding and monitor. Severe hepatic impairment: not recommended. Elderly. Pregnancy. Nursing mothers: not recommended.

Zontivity Pharmacokinetics

See Literature

Zontivity Interactions


Avoid concomitant strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin, conivaptan). Avoid concomitant strong CYP3A4 inducers (eg, rifampin, carbamazepine, St. John’s wort, phenytoin). Avoid concomitant warfarin or other anticoagulants. Increased risk of bleeding with concomitant fibrinolytics, chronic NSAIDs, SSRIs, SNRIs.

Zontivity Adverse Reactions

Adverse Reactions

Bleeding (may be fatal), anemia, depression, rashes, eruptions, exanthemas, iron deficiency, retinopathy or retinal disorder, diplopia/oculomotor disturbances.

Zontivity Clinical Trials

See Literature

Zontivity Note

Not Applicable

Zontivity Patient Counseling

See Literature