• Seizure disorders

Zonegran Generic Name & Formulations

General Description

Zonisamide 25mg, 100mg; caps.

Pharmacological Class

Carbonic anhydrase inhibitor (sulfonamide).

How Supplied


Zonegran Indications


Adjunct in partial seizures.

Zonegran Dosage and Administration


Swallow whole. ≥16yrs: initially 100mg once daily; may increase at intervals of at least 2 weeks by 100mg/day in 1 or 2 divided doses. Usual range: 100–400mg/day in 1 or 2 divided doses; usual max 600mg/day.


<16yrs: not established.

Zonegran Contraindications

Not Applicable

Zonegran Boxed Warnings

Not Applicable

Zonegran Warnings/Precautions


Discontinue or monitor closely if serious rash occurs. Evaluate immediately if signs/symptoms of DRESS/multi-organ hypersensitivity develop; discontinue if no alternative etiology. Renal failure: not recommended. Renal or hepatic impairment: titrate more slowly and monitor more frequently. Acute myopia. Secondary angle closure glaucoma. Depression. Suicidal tendencies (monitor). Maintain adequate hydration. Exposure to extreme heat; monitor closely for oligohidrosis and hyperthermia (esp. children). Measure baseline serum bicarbonate and periodically during treatment; consider reducing dose or discontinuing if metabolic acidosis occurs. Avoid abrupt cessation. Advise women of childbearing potential to use effective contraception. Elderly. Labor & delivery. Newborns. Pregnancy. Nursing mothers: not recommended.

Zonegran Pharmacokinetics

See Literature

Zonegran Interactions


Antagonized by CYP3A4 inducers (eg, phenytoin, carbamazepine, phenobarbital); may need to adjust zonisamide dose. Increased severity of metabolic acidosis, risk of kidney stone formation or hyperammonemia with concomitant other carbonic anhydrase inhibitors (eg, topiramate, acetazolamide, dichlorphenamide); monitor. Caution with other drugs that interfere with temperature regulation (eg, anticholinergics, carbonic anhydrase inhibitors). Caution with concomitant alcohol, other CNS depressants, or P-gp substrates (eg, digoxin, quinidine).

Zonegran Adverse Reactions

Adverse Reactions

CNS effects (eg, somnolence, anorexia, dizziness, headache, agitation, fatigue, ataxia, confusion, difficulty with memory and/or concentration, depression, insomnia, abnormal vision or speech), GI upset/pain, paresthesia; kidney stones, metabolic acidosis, hyperammonemia, encephalopathy; rarely: Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, aplastic anemia, agranulocytosis, oligohidrosis, hyperthermia.

Zonegran Clinical Trials

See Literature

Zonegran Note


To enroll pregnant patients in the North American Antiepileptic Drug Pregnancy Registry, call (888) 233-2334.

Zonegran Patient Counseling

See Literature