Zoladex 3-month 10.8mg Generic Name & Formulations
Goserelin (as acetate) 10.8mg; SC implant.
Implant (in syringe)—1
Mechanism of Action
Zoladex is a synthetic decapeptide analogue of GnRH. It acts as an inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation.
Zoladex 3-month 10.8mg Indications
Palliative treatment of advanced prostate carcinoma. In combination with flutamide for management of locally confined Stage T2b-T4 (Stage B2-C) prostate carcinoma.
Zoladex 3-month 10.8mg Dosage and Administration
Implant SC into anterior abdominal wall. Prostate cancer: one 3.6mg implant every 28 days or one 10.8mg implant every 12 weeks. Stage B2-C prostatic carcinoma (in combination with flutamide): Treat 8 weeks prior to and during radiotherapy. Initially one 3.6mg implant, followed in 28 days by one 10.8mg implant; or may use one 3.6mg implant every 28 days (two before and two during radiotherapy).
Zoladex 3-month 10.8mg Contraindications
Zoladex 3-month 10.8mg Boxed Warnings
Zoladex 3-month 10.8mg Warnings/Precautions
Increased risk of diabetes, MI, sudden cardiac death, stroke; monitor blood glucose and for signs/symptoms of CVD during therapy. Risk of ureteral obstruction or spinal cord compression; monitor during 1st month of therapy. Risk factors for decreased bone mineral density (eg, chronic alcohol, tobacco, anticonvulsants, corticosteroids). Risk of QT prolongation in congenital long QT syndrome, CHF, electrolyte abnormalities; monitor EKG and correct electrolyte abnormalities if needed. Risk of inj site injury in patients with low BMI and/or receiving full dose anticoagulation. Obesity; monitor testosterone if no clinical response. Nursing mothers: not recommended.
Zoladex 3-month 10.8mg Pharmacokinetics
Plasma protein bound: 27.3%.
Renal (>90%). Half-life: 4–5 hours.
Zoladex 3-month 10.8mg Interactions
Avoid concomitant drugs known to prolong the QT interval. May affect tests of pituitary-gonadotropic and gonadal functions.
Zoladex 3-month 10.8mg Adverse Reactions
Decreased testosterone levels (eg, hot flashes, sexual dysfunction, decreased erections, gynecomastia), lower urinary tract symptoms, transient worsening of symptoms (eg, bone pain), tumor flare, diarrhea, nausea, edema, malaise, hyperglycemia, hypercalcemia, decreased bone mineral density, QT prolongation.
Zoladex 3-month 10.8mg Clinical Trials
Zoladex 3-month 10.8mg Note
Zoladex 3-month 10.8mg Patient Counseling